Cargando…

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Cysteine plays critical roles in cellular biosynthesis, enzyme catalysis, and redox metabolism. The intracellular cysteine pool can be sustained by cystine uptake or de novo synthesis from serine and homocysteine. Demand for cysteine is increased during tumorigenesis for generating glutathione to de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoon, Sang Jun, Combs, Joseph A., Falzone, Aimee, Prieto-Farigua, Nicolas, Caldwell, Samantha, Ackerman, Hayley D., Flores, Elsa R., DeNicola, Gina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Cancer Metabolism and Molecular Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152234/ https://www.ncbi.nlm.nih.gov/pubmed/36862034 http://dx.doi.org/10.1158/0008-5472.CAN-22-3000

Ejemplares similares

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
por: DeBlasi, Janine M., et al.
Publicado: (2023)

ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma
por: Sun, Yan, et al.
Publicado: (2023)

circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma
por: Li, Xiang, et al.
Publicado: (2023)

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis
por: Mukherjee, Debarati, et al.
Publicado: (2023)

ESRRB Inhibits the TGFβ Signaling Pathway to Drive Cell Proliferation in Cervical Cancer
por: Li, Qin-Shu, et al.
Publicado: (2023)

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
por: Kong, Yao, et al.
Publicado: (2023)

Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
por: Zheng, Yannan, et al.
Publicado: (2023)

Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression
por: Zhou, Lijie, et al.
Publicado: (2023)

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
por: Burger, Karen L., et al.
Publicado: (2023)

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
por: Torrente, Laura, et al.
Publicado: (2020)

The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
por: Combs, Joseph A., et al.
Publicado: (2019)

Correction: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
por: Kang, Yun Pyo, et al.
Publicado: (2019)

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
por: Kang, Yun Pyo, et al.
Publicado: (2019)

Multiple Endocrine Neoplasia Type 1 (MEN1) as a Cancer Predisposition Syndrome: Clues into the Mechanisms of MEN1-related Carcinogenesis
por: Busygina, Valeria, et al.
Publicado: (2007)

Why Cancer and Inflammation?
por: Rakoff-Nahoum, Seth
Publicado: (2007)

Viruses and Human Cancer
por: Liao, John B
Publicado: (2007)

Mechanisms of Oncogenic Cooperation in Cancer Initiation and Metastasis
por: Pedraza-Fariña, Laura G.
Publicado: (2007)

The Role of MicroRNAs in Cancer
por: Stahlhut Espinosa, Carlos E., et al.
Publicado: (2007)

The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256‐17 includes trace amine‐associated receptor ligands
por: Tazir, Bassim, et al.
Publicado: (2016)

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
por: Zhou, Meiyi, et al.
Publicado: (2019)

A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer
por: Jiang, Chang, et al.
Publicado: (2022)

Corrigendum to “A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer” [Redox Biol. 54 (2022) 102358]
por: Jiang, Chang, et al.
Publicado: (2022)

Enzyme-independent catabolism of cysteine with pyridoxal-5′-phosphate
por: Mulay, Prajakatta, et al.
Publicado: (2023)

Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function
por: Ward, Nathan P., et al.
Publicado: (2020)

Mammalian lipids: structure, synthesis and function
por: Cockcroft, Shamshad
Publicado: (2021)

Catabolic flexibility of mammalian-associated lactobacilli
por: O’Donnell, Michelle M, et al.
Publicado: (2013)

Neoadjuvant FOLFIRINOX Therapy Is Associated with Increased Effector T Cells and Reduced Suppressor Cells in Patients with Pancreatic Cancer
por: Peng, Hui, et al.
Publicado: (2021)

Dopamine suppresses persistent network activity via D(1)-like dopamine receptors in rat medial entorhinal cortex
por: Mayne, Elizabeth W, et al.
Publicado: (2013)

GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses
por: Fuchs, Celine, et al.
Publicado: (2013)

The TIR-domain-containing adapter inducing interferon-β-dependent signaling cascade plays a crucial role in ischemia–reperfusion-induced retinal injury, whereas the contribution of the myeloid differentiation primary response 88-dependent signaling cascade is not as pivotal
por: Dvoriantchikova, Galina, et al.
Publicado: (2014)

Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus
por: Bright, Damian P, et al.
Publicado: (2013)

Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways
por: Dvoriantchikova, Galina, et al.
Publicado: (2014)

Mechanisms regulating spill‐over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons
por: Wild, A. R., et al.
Publicado: (2015)

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA(A) receptor-mediated inhibition
por: Herd, Murray B, et al.
Publicado: (2014)

Role of G(o/i) subgroup of G proteins in olfactory signaling of Drosophila melanogaster
por: Ignatious Raja, Jennifer S, et al.
Publicado: (2014)

Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates
por: Glazewski, Stanislaw, et al.
Publicado: (2015)

Shedding light on mitochondrial movements in axons (Commentary on Obashi & Okabe)
por: Vaccaro, Victoria, et al.
Publicado: (2013)

Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease
por: Jackson, Rosemary J., et al.
Publicado: (2016)

Brain‐derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells
por: Binley, Kate E., et al.
Publicado: (2016)

Loss of the calcium channel β(4) subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice
por: Benedetti, Bruno, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_c2vsjk9mu3deg2v7co5mbm8faq