Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy

IMPORTANCE: Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy subtype and is often refractory to antiseizure medications. While most patients with MTLE do not have pathogenic germline genetic variants, the contribution of postzygotic (ie, somatic) variants in the brain is unknow...

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Detalles Bibliográficos
Autores principales: Khoshkhoo, Sattar, Wang, Yilan, Chahine, Yasmine, Erson-Omay, E. Zeynep, Robert, Stephanie M., Kiziltug, Emre, Damisah, Eyiyemisi C., Nelson-Williams, Carol, Zhu, Guangya, Kong, Wenna, Huang, August Yue, Stronge, Edward, Phillips, H. Westley, Chhouk, Brian H., Bizzotto, Sara, Chen, Ming Hui, Adikari, Thiuni N., Ye, Zimeng, Witkowski, Tom, Lai, Dulcie, Lee, Nadine, Lokan, Julie, Scheffer, Ingrid E., Berkovic, Samuel F., Haider, Shozeb, Hildebrand, Michael S., Yang, Edward, Gunel, Murat, Lifton, Richard P., Richardson, R. Mark, Blümcke, Ingmar, Alexandrescu, Sanda, Huttner, Anita, Heinzen, Erin L., Zhu, Jidong, Poduri, Annapurna, DeLanerolle, Nihal, Spencer, Dennis D., Lee, Eunjung Alice, Walsh, Christopher A., Kahle, Kristopher T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152377/
https://www.ncbi.nlm.nih.gov/pubmed/37126322
http://dx.doi.org/10.1001/jamaneurol.2023.0473

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