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An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective

The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient...

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Autores principales: Salzberger, Bernd, Mellmann, Alexander, Bludau, Anna, Ciesek, Sandra, Corman, Victor, Dilthey, Alexander, Donker, Tjibbe, Eckmanns, Tim, Egelkamp, Richard, Gatermann, Sören G., Grundmann, Hajo, Häcker, Georg, Kaase, Martin, Lange, Berit, Mielke, Martin, Pletz, Mathias W., Semmler, Torsten, Thürmer, Andrea, Wieler, Lothar H., Wolff, Thorsten, Widmer, Andreas F., Scheithauer, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152431/
https://www.ncbi.nlm.nih.gov/pubmed/37129842
http://dx.doi.org/10.1007/s15010-023-02040-9
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author Salzberger, Bernd
Mellmann, Alexander
Bludau, Anna
Ciesek, Sandra
Corman, Victor
Dilthey, Alexander
Donker, Tjibbe
Eckmanns, Tim
Egelkamp, Richard
Gatermann, Sören G.
Grundmann, Hajo
Häcker, Georg
Kaase, Martin
Lange, Berit
Mielke, Martin
Pletz, Mathias W.
Semmler, Torsten
Thürmer, Andrea
Wieler, Lothar H.
Wolff, Thorsten
Widmer, Andreas F.
Scheithauer, Simone
author_facet Salzberger, Bernd
Mellmann, Alexander
Bludau, Anna
Ciesek, Sandra
Corman, Victor
Dilthey, Alexander
Donker, Tjibbe
Eckmanns, Tim
Egelkamp, Richard
Gatermann, Sören G.
Grundmann, Hajo
Häcker, Georg
Kaase, Martin
Lange, Berit
Mielke, Martin
Pletz, Mathias W.
Semmler, Torsten
Thürmer, Andrea
Wieler, Lothar H.
Wolff, Thorsten
Widmer, Andreas F.
Scheithauer, Simone
author_sort Salzberger, Bernd
collection PubMed
description The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient use of equipment, human resources, data management and coordination. The experience in other countries has shown that the rate of sequenced positive samples and linkage of genomic and epidemiological data (person, place, time) represent important factors for a successful application of genomic pathogen surveillance. Planning, establishing and consistently supporting adequate structures for genomic pathogen surveillance will be crucial to identify and combat future pandemics as well as other challenges in infectious diseases such as multi-drug resistant bacteria and healthcare-associated infections. Therefore, the authors propose a multifaceted and coordinated process for the definition of procedural, legal and technical standards for comprehensive genomic pathogen surveillance in Germany, covering the areas of genomic sequencing, data collection and data linkage, as well as target pathogens. A comparative analysis of the structures established in Germany and in other countries is applied. This proposal aims to better tackle epi- and pandemics to come and take action from the “lessons learned” from the SARS-CoV-2 pandemic.
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spelling pubmed-101524312023-05-03 An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective Salzberger, Bernd Mellmann, Alexander Bludau, Anna Ciesek, Sandra Corman, Victor Dilthey, Alexander Donker, Tjibbe Eckmanns, Tim Egelkamp, Richard Gatermann, Sören G. Grundmann, Hajo Häcker, Georg Kaase, Martin Lange, Berit Mielke, Martin Pletz, Mathias W. Semmler, Torsten Thürmer, Andrea Wieler, Lothar H. Wolff, Thorsten Widmer, Andreas F. Scheithauer, Simone Infection Position Statement The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient use of equipment, human resources, data management and coordination. The experience in other countries has shown that the rate of sequenced positive samples and linkage of genomic and epidemiological data (person, place, time) represent important factors for a successful application of genomic pathogen surveillance. Planning, establishing and consistently supporting adequate structures for genomic pathogen surveillance will be crucial to identify and combat future pandemics as well as other challenges in infectious diseases such as multi-drug resistant bacteria and healthcare-associated infections. Therefore, the authors propose a multifaceted and coordinated process for the definition of procedural, legal and technical standards for comprehensive genomic pathogen surveillance in Germany, covering the areas of genomic sequencing, data collection and data linkage, as well as target pathogens. A comparative analysis of the structures established in Germany and in other countries is applied. This proposal aims to better tackle epi- and pandemics to come and take action from the “lessons learned” from the SARS-CoV-2 pandemic. Springer Berlin Heidelberg 2023-05-02 2023 /pmc/articles/PMC10152431/ /pubmed/37129842 http://dx.doi.org/10.1007/s15010-023-02040-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Position Statement
Salzberger, Bernd
Mellmann, Alexander
Bludau, Anna
Ciesek, Sandra
Corman, Victor
Dilthey, Alexander
Donker, Tjibbe
Eckmanns, Tim
Egelkamp, Richard
Gatermann, Sören G.
Grundmann, Hajo
Häcker, Georg
Kaase, Martin
Lange, Berit
Mielke, Martin
Pletz, Mathias W.
Semmler, Torsten
Thürmer, Andrea
Wieler, Lothar H.
Wolff, Thorsten
Widmer, Andreas F.
Scheithauer, Simone
An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title_full An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title_fullStr An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title_full_unstemmed An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title_short An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
title_sort appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the german perspective
topic Position Statement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152431/
https://www.ncbi.nlm.nih.gov/pubmed/37129842
http://dx.doi.org/10.1007/s15010-023-02040-9
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