Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis

[Image: see text] Three new benzo[b]naphtho[2,1-d]furans, usambarins A–C (1–3), five new 2-phenylnaphthalenes, usambarins D–H (4–8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usamba...

Descripción completa

Detalles Bibliográficos
Autores principales: Chepkirui, Carolyne, Ali Adem, Fozia, Rudenko, Anastasia, Gütlin, Yukino, Ndakala, Albert, Derese, Solomon, Orthaber, Andreas, Bourgard, Catarina, Yenesew, Abiy, Erdélyi, Máté
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152483/
https://www.ncbi.nlm.nih.gov/pubmed/37043719
http://dx.doi.org/10.1021/acs.jnatprod.3c00051
Descripción
Sumario:[Image: see text] Three new benzo[b]naphtho[2,1-d]furans, usambarins A–C (1–3), five new 2-phenylnaphthalenes, usambarins D–H (4–8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usambarensis (Moraceae). The structures were deduced using NMR spectroscopic and mass spectrometric analyses, and those of compounds 1 and 4 were confirmed by X-ray crystallography. Usambarin D (4) demonstrated moderate antibacterial activity (MIC 9.0 μM) against Bacillus subtilis, while none of the tested compounds were effective against Escherichia coli.

Ejemplares similares