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Mitochondria-derived vesicles and their potential roles in kidney stone disease

Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be...

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Detalles Bibliográficos
Autores principales: Chaiyarit, Sakdithep, Thongboonkerd, Visith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152607/
https://www.ncbi.nlm.nih.gov/pubmed/37131163
http://dx.doi.org/10.1186/s12967-023-04133-3
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author Chaiyarit, Sakdithep
Thongboonkerd, Visith
author_facet Chaiyarit, Sakdithep
Thongboonkerd, Visith
author_sort Chaiyarit, Sakdithep
collection PubMed
description Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.
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spelling pubmed-101526072023-05-03 Mitochondria-derived vesicles and their potential roles in kidney stone disease Chaiyarit, Sakdithep Thongboonkerd, Visith J Transl Med Review Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized. BioMed Central 2023-05-02 /pmc/articles/PMC10152607/ /pubmed/37131163 http://dx.doi.org/10.1186/s12967-023-04133-3 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chaiyarit, Sakdithep
Thongboonkerd, Visith
Mitochondria-derived vesicles and their potential roles in kidney stone disease
title Mitochondria-derived vesicles and their potential roles in kidney stone disease
title_full Mitochondria-derived vesicles and their potential roles in kidney stone disease
title_fullStr Mitochondria-derived vesicles and their potential roles in kidney stone disease
title_full_unstemmed Mitochondria-derived vesicles and their potential roles in kidney stone disease
title_short Mitochondria-derived vesicles and their potential roles in kidney stone disease
title_sort mitochondria-derived vesicles and their potential roles in kidney stone disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152607/
https://www.ncbi.nlm.nih.gov/pubmed/37131163
http://dx.doi.org/10.1186/s12967-023-04133-3
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