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Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge
Kimura disease (KD) is an unusual inflammatory disease of unknown etiology. Despite being described many years ago, KD might cause diagnostic difficulty or be confused with other conditions. Here, we present a 33-year-old Filipino woman who was referred to our hospital for evaluation of persistent e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Croatian Society of Medical Biochemistry and Laboratory Medicine
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152615/ https://www.ncbi.nlm.nih.gov/pubmed/37143713 http://dx.doi.org/10.11613/BM.2023.020801 |
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author | Laguna, Javier Rodríguez-García, María Molina, Angel Merino, Anna |
author_facet | Laguna, Javier Rodríguez-García, María Molina, Angel Merino, Anna |
author_sort | Laguna, Javier |
collection | PubMed |
description | Kimura disease (KD) is an unusual inflammatory disease of unknown etiology. Despite being described many years ago, KD might cause diagnostic difficulty or be confused with other conditions. Here, we present a 33-year-old Filipino woman who was referred to our hospital for evaluation of persistent eosinophilia and intense pruritus. Blood analysis and peripheral blood smear review showed high eosinophil counts (3.8 x10(9)/L, 40%) that did not show morphological abnormalities. Besides, high serum IgE concentration was detected (33,528 kU/L). Serological tests were positive for Toxocara canis and treatment with albendazol was initiated. Nevertheless, increased eosinophil counts were still present after several months, alongside with high serum IgE concentrations and intense pruritus. During her follow-up, an inguinal adenopathy was detected. The biopsy revealed lymphoid hyperplasia with reactive germinal centers and massive eosinophil infiltration. Proteinaceous deposits of eosinophilic material were also observed. All these findings, together with peripheral blood eosinophilia and high IgE concentrations, confirmed the diagnosis of KD. The diagnosis of KD should be considered in the differential diagnosis of long-standing unexplained eosinophilia in association with high IgE concentrations, pruritus and lymphadenopathies. |
format | Online Article Text |
id | pubmed-10152615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Croatian Society of Medical Biochemistry and Laboratory Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-101526152023-05-03 Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge Laguna, Javier Rodríguez-García, María Molina, Angel Merino, Anna Biochem Med (Zagreb) Case Reports Kimura disease (KD) is an unusual inflammatory disease of unknown etiology. Despite being described many years ago, KD might cause diagnostic difficulty or be confused with other conditions. Here, we present a 33-year-old Filipino woman who was referred to our hospital for evaluation of persistent eosinophilia and intense pruritus. Blood analysis and peripheral blood smear review showed high eosinophil counts (3.8 x10(9)/L, 40%) that did not show morphological abnormalities. Besides, high serum IgE concentration was detected (33,528 kU/L). Serological tests were positive for Toxocara canis and treatment with albendazol was initiated. Nevertheless, increased eosinophil counts were still present after several months, alongside with high serum IgE concentrations and intense pruritus. During her follow-up, an inguinal adenopathy was detected. The biopsy revealed lymphoid hyperplasia with reactive germinal centers and massive eosinophil infiltration. Proteinaceous deposits of eosinophilic material were also observed. All these findings, together with peripheral blood eosinophilia and high IgE concentrations, confirmed the diagnosis of KD. The diagnosis of KD should be considered in the differential diagnosis of long-standing unexplained eosinophilia in association with high IgE concentrations, pruritus and lymphadenopathies. Croatian Society of Medical Biochemistry and Laboratory Medicine 2023-04-15 2023-06-15 /pmc/articles/PMC10152615/ /pubmed/37143713 http://dx.doi.org/10.11613/BM.2023.020801 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Laguna, Javier Rodríguez-García, María Molina, Angel Merino, Anna Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title | Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title_full | Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title_fullStr | Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title_full_unstemmed | Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title_short | Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
title_sort | kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152615/ https://www.ncbi.nlm.nih.gov/pubmed/37143713 http://dx.doi.org/10.11613/BM.2023.020801 |
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