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Malaria prevalence in Mauritania: a systematic review and meta-analysis
BACKGROUND: Understanding malaria epidemiology is a critical step toward efficient malaria control and elimination. The objective of this meta-analysis was to derive robust estimates of malaria prevalence and Plasmodium species from studies conducted in Mauritania and published since 2000. METHODS:...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152621/ https://www.ncbi.nlm.nih.gov/pubmed/37131226 http://dx.doi.org/10.1186/s12936-023-04569-4 |
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author | El Moustapha, Inejih Ouldabdallahi Moukah, Mohamed Ould Ahmedou Salem, Mohamed Salem Brahim, Khyarhoum Briolant, Sébastien Basco, Leonardo Ould Mohamed Salem Boukhary, Ali |
author_facet | El Moustapha, Inejih Ouldabdallahi Moukah, Mohamed Ould Ahmedou Salem, Mohamed Salem Brahim, Khyarhoum Briolant, Sébastien Basco, Leonardo Ould Mohamed Salem Boukhary, Ali |
author_sort | El Moustapha, Inejih |
collection | PubMed |
description | BACKGROUND: Understanding malaria epidemiology is a critical step toward efficient malaria control and elimination. The objective of this meta-analysis was to derive robust estimates of malaria prevalence and Plasmodium species from studies conducted in Mauritania and published since 2000. METHODS: The present review followed the PRISMA guidelines. Searches were conducted in various electronic databases such as PubMed, Web of Science, and Scopus. To obtain pooled prevalence of malaria, meta-analysis was performed using the DerSimonian-Laird random-effects model. Methodological quality of eligible prevalence studies was assessed using Joanna Briggs Institute tool. Inconsistency and heterogeneity between studies were quantified by the I(2) index and Cochran’s Q test. Publication bias was assessed with funnel plots and Egger’s regression tests. RESULTS: A total of 16 studies with a good individual methodological quality were included and analysed in this study. The overall random effects pooled prevalence of malaria infection (symptomatic and asymptomatic) across all included studies was 14.9% (95% confidence interval [95% CI]: 6.64, 25.80, I(2) = 99.8%, P < 0.0001) by microscopy, 25.6% (95% CI: 8.74, 47.62, I(2) = 99.6%, P < 0.0001) by PCR and 24.3% (95% CI: 12.05 to 39.14, I(2) = 99.7%, P < 0.0001) by rapid diagnostic test. Using microscopy, the prevalence of asymptomatic malaria was 1.0% (95% CI: 0.00, 3.48) against 21.46% (95% CI: 11.03, 34.21) in symptomatic malaria. The overall prevalence of Plasmodium falciparum and Plasmodium vivax was 51.14% and 37.55%, respectively. Subgroup analysis showed significant variation (P = 0.039) in the prevalence of malaria between asymptomatic and symptomatic cases. CONCLUSION: Plasmodium falciparum and P. vivax are widespread in Mauritania. Results of this meta-analysis implies that distinct intervention measures including accurate parasite-based diagnosis and appropriate treatment of confirmed malaria cases are critical for a successful malaria control and elimination programme in Mauritania. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12936-023-04569-4. |
format | Online Article Text |
id | pubmed-10152621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101526212023-05-03 Malaria prevalence in Mauritania: a systematic review and meta-analysis El Moustapha, Inejih Ouldabdallahi Moukah, Mohamed Ould Ahmedou Salem, Mohamed Salem Brahim, Khyarhoum Briolant, Sébastien Basco, Leonardo Ould Mohamed Salem Boukhary, Ali Malar J Research BACKGROUND: Understanding malaria epidemiology is a critical step toward efficient malaria control and elimination. The objective of this meta-analysis was to derive robust estimates of malaria prevalence and Plasmodium species from studies conducted in Mauritania and published since 2000. METHODS: The present review followed the PRISMA guidelines. Searches were conducted in various electronic databases such as PubMed, Web of Science, and Scopus. To obtain pooled prevalence of malaria, meta-analysis was performed using the DerSimonian-Laird random-effects model. Methodological quality of eligible prevalence studies was assessed using Joanna Briggs Institute tool. Inconsistency and heterogeneity between studies were quantified by the I(2) index and Cochran’s Q test. Publication bias was assessed with funnel plots and Egger’s regression tests. RESULTS: A total of 16 studies with a good individual methodological quality were included and analysed in this study. The overall random effects pooled prevalence of malaria infection (symptomatic and asymptomatic) across all included studies was 14.9% (95% confidence interval [95% CI]: 6.64, 25.80, I(2) = 99.8%, P < 0.0001) by microscopy, 25.6% (95% CI: 8.74, 47.62, I(2) = 99.6%, P < 0.0001) by PCR and 24.3% (95% CI: 12.05 to 39.14, I(2) = 99.7%, P < 0.0001) by rapid diagnostic test. Using microscopy, the prevalence of asymptomatic malaria was 1.0% (95% CI: 0.00, 3.48) against 21.46% (95% CI: 11.03, 34.21) in symptomatic malaria. The overall prevalence of Plasmodium falciparum and Plasmodium vivax was 51.14% and 37.55%, respectively. Subgroup analysis showed significant variation (P = 0.039) in the prevalence of malaria between asymptomatic and symptomatic cases. CONCLUSION: Plasmodium falciparum and P. vivax are widespread in Mauritania. Results of this meta-analysis implies that distinct intervention measures including accurate parasite-based diagnosis and appropriate treatment of confirmed malaria cases are critical for a successful malaria control and elimination programme in Mauritania. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12936-023-04569-4. BioMed Central 2023-05-02 /pmc/articles/PMC10152621/ /pubmed/37131226 http://dx.doi.org/10.1186/s12936-023-04569-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research El Moustapha, Inejih Ouldabdallahi Moukah, Mohamed Ould Ahmedou Salem, Mohamed Salem Brahim, Khyarhoum Briolant, Sébastien Basco, Leonardo Ould Mohamed Salem Boukhary, Ali Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title | Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title_full | Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title_fullStr | Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title_full_unstemmed | Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title_short | Malaria prevalence in Mauritania: a systematic review and meta-analysis |
title_sort | malaria prevalence in mauritania: a systematic review and meta-analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152621/ https://www.ncbi.nlm.nih.gov/pubmed/37131226 http://dx.doi.org/10.1186/s12936-023-04569-4 |
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