Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

BACKGROUND: Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ) deposits in Alzheimer’s disease (AD). In the present study, we compared the therapeutic efficacy of the Aβ protofibril targeting antibody RmAb158 with its bispecific variant RmAb158-scFv8D3, which enters the br...

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Detalles Bibliográficos
Autores principales: Gustavsson, Tobias, Metzendorf, Nicole G., Wik, Elin, Roshanbin, Sahar, Julku, Ulrika, Chourlia, Aikaterini, Nilsson, Per, Andersson, Ken G., Laudon, Hanna, Hultqvist, Greta, Syvänen, Stina, Sehlin, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152635/
https://www.ncbi.nlm.nih.gov/pubmed/37131196
http://dx.doi.org/10.1186/s13195-023-01236-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152635/
https://www.ncbi.nlm.nih.gov/pubmed/37131196
http://dx.doi.org/10.1186/s13195-023-01236-3

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