First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

BACKGROUND: The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC), owing to their well documented phagocytosis-driven mechanism of immunomodulati...

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Detalles Bibliográficos
Autores principales: Siddiqui, Fyyaz, Gallagher, Denis, Shuster-Hyman, Hannah, Lopez, Lianet, Gauthier-Fisher, Andrée, Librach, Clifford L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152638/
https://www.ncbi.nlm.nih.gov/pubmed/37127610
http://dx.doi.org/10.1186/s12950-023-00340-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152638/
https://www.ncbi.nlm.nih.gov/pubmed/37127610
http://dx.doi.org/10.1186/s12950-023-00340-3

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