CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways

BACKGROUND: The ischemia–reperfusion (IR) environment during deep hypothermic circulatory arrest (DHCA) cardiovascular surgery is a major cause of acute kidney injury (AKI), which lacks preventive measure and treatment. It was reported that cold inducible RNA-binding protein (CIRP) can be induced un...

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Detalles Bibliográficos
Autores principales: Zhang, Peiyao, Bai, Liting, Tong, Yuanyuan, Guo, Shengwen, Lu, Wenlong, Yuan, Yue, Wang, Wenting, Jin, Yu, Gao, Peng, Liu, Jinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152741/
https://www.ncbi.nlm.nih.gov/pubmed/37127576
http://dx.doi.org/10.1186/s10020-023-00655-0

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