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Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan

BACKGROUND: Leukemia frequently causes anemia; thus patients need products containing normal blood or RBCs for treatment. Anti-red blood cell alloantibody formation is still a critical challenge in transfusion. OBJECTIVES: The current study aimed to investigate RBC alloantibodies in Sudanese leukemi...

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Autores principales: Abdalkream Jawish, Taj Alasfia, Hessen, Hajir Mohamed, Alshafeea, Mubarak Ahmed, Mohamedahmed, Khalid Abdelsamea, Ahmed, Elhadi Abdella, Modawe, Gad Allah, Ibrahim, Ibrahim Khider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152849/
https://www.ncbi.nlm.nih.gov/pubmed/36708548
http://dx.doi.org/10.31557/APJCP.2023.24.1.21
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author Abdalkream Jawish, Taj Alasfia
Hessen, Hajir Mohamed
Alshafeea, Mubarak Ahmed
Mohamedahmed, Khalid Abdelsamea
Ahmed, Elhadi Abdella
Modawe, Gad Allah
Ibrahim, Ibrahim Khider
author_facet Abdalkream Jawish, Taj Alasfia
Hessen, Hajir Mohamed
Alshafeea, Mubarak Ahmed
Mohamedahmed, Khalid Abdelsamea
Ahmed, Elhadi Abdella
Modawe, Gad Allah
Ibrahim, Ibrahim Khider
author_sort Abdalkream Jawish, Taj Alasfia
collection PubMed
description BACKGROUND: Leukemia frequently causes anemia; thus patients need products containing normal blood or RBCs for treatment. Anti-red blood cell alloantibody formation is still a critical challenge in transfusion. OBJECTIVES: The current study aimed to investigate RBC alloantibodies in Sudanese leukemia patients who receive multiple blood transfusions at the cancer center in Dongola and Maroyee, Northern Sudan. MATERIALS AND METHODS: At the Northern State oncology center in Dongola and Maroyee, Sudan, an across-sectional descriptive study design was used. In this study, 100 leukemic patients who had received blood transfusions three times or more were enrolled. From each participant, Peripheral blood was drawn in amounts of 3 ml in EDTA vacutainer tubes for ABO blood group and Rh factor testing and 3 ml in non-additive containers for antibody screening and Alloantibody identification. All individuals’ ABO blood groups and Rh factors were determined using the slide method. Indirect Coombs test apply to detect alloantibodies by Polly Specific antihuman globulin reagents using tube method techniques. Alloantibody identification was performed by DiaMed-ID microtyping system. RESULTS: Incidence of alloimmunization was 11%, with 11 alloantibodies found in 11 patients. The most common alloantibody was kell (36.4%), followed by Lea (27.2%; 3/11), then P (18.2%; 2/11) and M (18.2%; 2/11). CONCLUSION: Anti kell antibody was the most prevalent alloantibody among leukemic patients with multiple transfusions.
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spelling pubmed-101528492023-05-03 Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan Abdalkream Jawish, Taj Alasfia Hessen, Hajir Mohamed Alshafeea, Mubarak Ahmed Mohamedahmed, Khalid Abdelsamea Ahmed, Elhadi Abdella Modawe, Gad Allah Ibrahim, Ibrahim Khider Asian Pac J Cancer Prev Short Communication BACKGROUND: Leukemia frequently causes anemia; thus patients need products containing normal blood or RBCs for treatment. Anti-red blood cell alloantibody formation is still a critical challenge in transfusion. OBJECTIVES: The current study aimed to investigate RBC alloantibodies in Sudanese leukemia patients who receive multiple blood transfusions at the cancer center in Dongola and Maroyee, Northern Sudan. MATERIALS AND METHODS: At the Northern State oncology center in Dongola and Maroyee, Sudan, an across-sectional descriptive study design was used. In this study, 100 leukemic patients who had received blood transfusions three times or more were enrolled. From each participant, Peripheral blood was drawn in amounts of 3 ml in EDTA vacutainer tubes for ABO blood group and Rh factor testing and 3 ml in non-additive containers for antibody screening and Alloantibody identification. All individuals’ ABO blood groups and Rh factors were determined using the slide method. Indirect Coombs test apply to detect alloantibodies by Polly Specific antihuman globulin reagents using tube method techniques. Alloantibody identification was performed by DiaMed-ID microtyping system. RESULTS: Incidence of alloimmunization was 11%, with 11 alloantibodies found in 11 patients. The most common alloantibody was kell (36.4%), followed by Lea (27.2%; 3/11), then P (18.2%; 2/11) and M (18.2%; 2/11). CONCLUSION: Anti kell antibody was the most prevalent alloantibody among leukemic patients with multiple transfusions. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10152849/ /pubmed/36708548 http://dx.doi.org/10.31557/APJCP.2023.24.1.21 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.https://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Short Communication
Abdalkream Jawish, Taj Alasfia
Hessen, Hajir Mohamed
Alshafeea, Mubarak Ahmed
Mohamedahmed, Khalid Abdelsamea
Ahmed, Elhadi Abdella
Modawe, Gad Allah
Ibrahim, Ibrahim Khider
Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title_full Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title_fullStr Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title_full_unstemmed Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title_short Red Cell Alloimmunization in Repeatedly Transfused Sudanese Patients with Leukemia in Northern Sudan
title_sort red cell alloimmunization in repeatedly transfused sudanese patients with leukemia in northern sudan
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152849/
https://www.ncbi.nlm.nih.gov/pubmed/36708548
http://dx.doi.org/10.31557/APJCP.2023.24.1.21
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