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MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression
OBJECTIVE: To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC. METHODS: Fifty female of EC were joined to this study. The gene expression...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152854/ https://www.ncbi.nlm.nih.gov/pubmed/36708573 http://dx.doi.org/10.31557/APJCP.2023.24.1.239 |
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author | Mosaada, Hala Abdelrahman, Aziza E Abdullatif, Asmaa Lashin, Mohamed El-Bakry Ramadan, Mohamed S H El-Azony, Ahmed Hussiena, Marwa H S |
author_facet | Mosaada, Hala Abdelrahman, Aziza E Abdullatif, Asmaa Lashin, Mohamed El-Bakry Ramadan, Mohamed S H El-Azony, Ahmed Hussiena, Marwa H S |
author_sort | Mosaada, Hala |
collection | PubMed |
description | OBJECTIVE: To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC. METHODS: Fifty female of EC were joined to this study. The gene expression of miR-379-5p (by quantitative real time-PCR) and ROR1 (by quantitative real time-PCR and immunohistochemistry) were studied in EC and normal nearby endometrial tissue. RESULTS: The gene expression of miR-379-5p was significantly downregulated while that of ROR1 was significantly upregulated in EC tissues compared to adjacent normal endometrial tissues. Furthermore, miR-379 and ROR1 expressions significantly associated with tumor stage (P< 0.045), grade (P< 0.001), myometrial invasion (P <0.001) and LN metastasis (P< 0.034). In addition, miR-3795p and ROR1 gene expression were negatively correlated (r = -0.746, P < 0.001). CONCLUSIONS: In EC, miR-379-5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR-379-5p. |
format | Online Article Text |
id | pubmed-10152854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-101528542023-05-03 MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression Mosaada, Hala Abdelrahman, Aziza E Abdullatif, Asmaa Lashin, Mohamed El-Bakry Ramadan, Mohamed S H El-Azony, Ahmed Hussiena, Marwa H S Asian Pac J Cancer Prev Research Article OBJECTIVE: To asses miR-379-5p expression in endometrial cancer (EC) and its correlation with ROR1 expression and to investigate the relation between miR-379-5p and ROR1 expressions and the clinicopathological picture of EC. METHODS: Fifty female of EC were joined to this study. The gene expression of miR-379-5p (by quantitative real time-PCR) and ROR1 (by quantitative real time-PCR and immunohistochemistry) were studied in EC and normal nearby endometrial tissue. RESULTS: The gene expression of miR-379-5p was significantly downregulated while that of ROR1 was significantly upregulated in EC tissues compared to adjacent normal endometrial tissues. Furthermore, miR-379 and ROR1 expressions significantly associated with tumor stage (P< 0.045), grade (P< 0.001), myometrial invasion (P <0.001) and LN metastasis (P< 0.034). In addition, miR-3795p and ROR1 gene expression were negatively correlated (r = -0.746, P < 0.001). CONCLUSIONS: In EC, miR-379-5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR-379-5p. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10152854/ /pubmed/36708573 http://dx.doi.org/10.31557/APJCP.2023.24.1.239 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.https://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Research Article Mosaada, Hala Abdelrahman, Aziza E Abdullatif, Asmaa Lashin, Mohamed El-Bakry Ramadan, Mohamed S H El-Azony, Ahmed Hussiena, Marwa H S MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title | MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title_full | MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title_fullStr | MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title_full_unstemmed | MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title_short | MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression |
title_sort | mir-379-5p expression in endometrial cancer and its correlation with ror1 expression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152854/ https://www.ncbi.nlm.nih.gov/pubmed/36708573 http://dx.doi.org/10.31557/APJCP.2023.24.1.239 |
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