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Binding Modes of Xanthine‐Derived Selective Allosteric Site Inhibitors of MTHFD2

Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2 which bind to its allosteric site. Xanthine d...

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Detalles Bibliográficos
Autores principales:	Jha, Vibhu, Eriksson, Leif A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152887/ https://www.ncbi.nlm.nih.gov/pubmed/37129313 http://dx.doi.org/10.1002/open.202300052

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