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Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease

One of the pathological hallmarks of Alzheimer’s and related diseases is the increased accumulation of protein amyloid-β in the brain parenchyma. As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studie...

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Autores principales: Song, Alexander K, Hett, Kilian, Eisma, Jarrod J, McKnight, Colin D, Elenberger, Jason, Stark, Adam J, Kang, Hakmook, Yan, Yan, Considine, Ciaran M, Donahue, Manus J, Claassen, Daniel O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152899/
https://www.ncbi.nlm.nih.gov/pubmed/37143860
http://dx.doi.org/10.1093/braincomms/fcad128
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author Song, Alexander K
Hett, Kilian
Eisma, Jarrod J
McKnight, Colin D
Elenberger, Jason
Stark, Adam J
Kang, Hakmook
Yan, Yan
Considine, Ciaran M
Donahue, Manus J
Claassen, Daniel O
author_facet Song, Alexander K
Hett, Kilian
Eisma, Jarrod J
McKnight, Colin D
Elenberger, Jason
Stark, Adam J
Kang, Hakmook
Yan, Yan
Considine, Ciaran M
Donahue, Manus J
Claassen, Daniel O
author_sort Song, Alexander K
collection PubMed
description One of the pathological hallmarks of Alzheimer’s and related diseases is the increased accumulation of protein amyloid-β in the brain parenchyma. As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studies of these pathways are limited owing to limited methods for evaluating neurofluid circulation non-invasively in vivo. Here, we utilize non-invasive MRI methods to explore surrogate measures of CSF production, bulk flow and egress in the context of independent PET measures of amyloid-β accumulation in older adults. Participants (N = 23) were scanned at 3.0 T with 3D T(2)-weighted turbo spin echo, 2D perfusion-weighted pseudo-continuous arterial spin labelling and phase-contrast angiography to quantify parasagittal dural space volume, choroid plexus perfusion and net CSF flow through the aqueduct of Sylvius, respectively. All participants also underwent dynamic PET imaging with amyloid-β tracer (11)C-Pittsburgh Compound B to quantify global cerebral amyloid-β accumulation. Spearman’s correlation analyses revealed a significant relationship between global amyloid-β accumulation and parasagittal dural space volume (rho = 0.529, P = 0.010), specifically in the frontal (rho = 0.527, P = 0.010) and parietal (rho = 0.616, P = 0.002) subsegments. No relationships were observed between amyloid-β and choroid plexus perfusion nor net CSF flow. Findings suggest that parasagittal dural space hypertrophy, and its possible role in CSF-mediated clearance, may be closely related to global amyloid-β accumulation. These findings are discussed in the context of our growing understanding of the physiological mechanisms of amyloid-β aggregation and clearance via neurofluids.
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spelling pubmed-101528992023-05-03 Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease Song, Alexander K Hett, Kilian Eisma, Jarrod J McKnight, Colin D Elenberger, Jason Stark, Adam J Kang, Hakmook Yan, Yan Considine, Ciaran M Donahue, Manus J Claassen, Daniel O Brain Commun Original Article One of the pathological hallmarks of Alzheimer’s and related diseases is the increased accumulation of protein amyloid-β in the brain parenchyma. As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studies of these pathways are limited owing to limited methods for evaluating neurofluid circulation non-invasively in vivo. Here, we utilize non-invasive MRI methods to explore surrogate measures of CSF production, bulk flow and egress in the context of independent PET measures of amyloid-β accumulation in older adults. Participants (N = 23) were scanned at 3.0 T with 3D T(2)-weighted turbo spin echo, 2D perfusion-weighted pseudo-continuous arterial spin labelling and phase-contrast angiography to quantify parasagittal dural space volume, choroid plexus perfusion and net CSF flow through the aqueduct of Sylvius, respectively. All participants also underwent dynamic PET imaging with amyloid-β tracer (11)C-Pittsburgh Compound B to quantify global cerebral amyloid-β accumulation. Spearman’s correlation analyses revealed a significant relationship between global amyloid-β accumulation and parasagittal dural space volume (rho = 0.529, P = 0.010), specifically in the frontal (rho = 0.527, P = 0.010) and parietal (rho = 0.616, P = 0.002) subsegments. No relationships were observed between amyloid-β and choroid plexus perfusion nor net CSF flow. Findings suggest that parasagittal dural space hypertrophy, and its possible role in CSF-mediated clearance, may be closely related to global amyloid-β accumulation. These findings are discussed in the context of our growing understanding of the physiological mechanisms of amyloid-β aggregation and clearance via neurofluids. Oxford University Press 2023-04-18 /pmc/articles/PMC10152899/ /pubmed/37143860 http://dx.doi.org/10.1093/braincomms/fcad128 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Alexander K
Hett, Kilian
Eisma, Jarrod J
McKnight, Colin D
Elenberger, Jason
Stark, Adam J
Kang, Hakmook
Yan, Yan
Considine, Ciaran M
Donahue, Manus J
Claassen, Daniel O
Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title_full Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title_fullStr Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title_full_unstemmed Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title_short Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease
title_sort parasagittal dural space hypertrophy and amyloid-β deposition in alzheimer’s disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152899/
https://www.ncbi.nlm.nih.gov/pubmed/37143860
http://dx.doi.org/10.1093/braincomms/fcad128
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