The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease

In sickle cell disease (SCD), heme released during intravascular hemolysis promotes oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate expression of antioxidant and globin genes. Heme binds to the transcription factor BACH1, which represses NRF2-mediated gene...

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Detalles Bibliográficos
Autores principales: Belcher, John D., Nataraja, Selvaraj, Abdulla, Fuad, Zhang, Ping, Chen, Chunsheng, Nguyen, Julia, Ruan, Conglin, Singh, Maneet, Demes, Shilpa, Olson, Lyndsay, Stickens, Domi, Stanwix, Jeff, Clarke, Emer, Huang, Yongzhao, Biddle, Margaret, Vercellotti, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152901/
https://www.ncbi.nlm.nih.gov/pubmed/37144034
http://dx.doi.org/10.3389/fmed.2023.1101501

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