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Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts
BACKGROUND: Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152995/ https://www.ncbi.nlm.nih.gov/pubmed/37040077 http://dx.doi.org/10.1093/jncics/pkad029 |
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author | Ampomah, Nana K Teles, Flavia Martin, Lynn M Lu, Jiayun Koestler, Devin C Kelsey, Karl T Beck, James D Platz, Elizabeth A Michaud, Dominique S |
author_facet | Ampomah, Nana K Teles, Flavia Martin, Lynn M Lu, Jiayun Koestler, Devin C Kelsey, Karl T Beck, James D Platz, Elizabeth A Michaud, Dominique S |
author_sort | Ampomah, Nana K |
collection | PubMed |
description | BACKGROUND: Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers. METHODS: Incident lung cancer cases (n = 192) and matched controls (n = 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression. RESULTS: Most of the periodontal bacterial antibodies measured were inversely associated with lung cancer risk; of these, 3 were statistically significant (Prevotellaintermedia, Actinomyces naeslundii, and Veillonella parvula). A statistically significant positive association was observed for one of the Porphyromonas gingivalis strains after adjusting for P. intermedia. The sum of the logarithm of antibodies against the 13 measured bacteria was inversely associated with risk of lung cancer when the analysis was restricted to a longer follow-up (31-44 years after blood collection, highest vs lowest quartile: odds ratio = 0.26, 95% confidence interval = 0.08 to 0.84). CONCLUSIONS: Findings from this study highlight the complexity of using serum IgG antibodies to periodontal bacteria to identify associations between oral pathogens and risk of lung cancer. The inverse associations observed for antibodies to periodontal bacteria suggest that these may represent markers of immunity that provide some advantage in reducing the development of lung cancer. |
format | Online Article Text |
id | pubmed-10152995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101529952023-05-03 Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts Ampomah, Nana K Teles, Flavia Martin, Lynn M Lu, Jiayun Koestler, Devin C Kelsey, Karl T Beck, James D Platz, Elizabeth A Michaud, Dominique S JNCI Cancer Spectr Article BACKGROUND: Oral health is a key indicator of overall health, well-being, and quality of life. Several studies have provided new evidence about the role of oral diseases, specifically periodontitis, in generating risk for various forms of cancers, including lung, colorectal, and pancreatic cancers. METHODS: Incident lung cancer cases (n = 192) and matched controls (n = 192) were selected from participants of the CLUE I and CLUE II cohorts. Archived serum samples collected from participants in 1974 (in CLUE I) were analyzed using immunoblotting for immunoglobulin G (IgG) antibody levels to 13 bacteria of the periodontium. Associations between antibody levels and lung cancer were estimated using conditional logistic regression. RESULTS: Most of the periodontal bacterial antibodies measured were inversely associated with lung cancer risk; of these, 3 were statistically significant (Prevotellaintermedia, Actinomyces naeslundii, and Veillonella parvula). A statistically significant positive association was observed for one of the Porphyromonas gingivalis strains after adjusting for P. intermedia. The sum of the logarithm of antibodies against the 13 measured bacteria was inversely associated with risk of lung cancer when the analysis was restricted to a longer follow-up (31-44 years after blood collection, highest vs lowest quartile: odds ratio = 0.26, 95% confidence interval = 0.08 to 0.84). CONCLUSIONS: Findings from this study highlight the complexity of using serum IgG antibodies to periodontal bacteria to identify associations between oral pathogens and risk of lung cancer. The inverse associations observed for antibodies to periodontal bacteria suggest that these may represent markers of immunity that provide some advantage in reducing the development of lung cancer. Oxford University Press 2023-04-11 /pmc/articles/PMC10152995/ /pubmed/37040077 http://dx.doi.org/10.1093/jncics/pkad029 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Article Ampomah, Nana K Teles, Flavia Martin, Lynn M Lu, Jiayun Koestler, Devin C Kelsey, Karl T Beck, James D Platz, Elizabeth A Michaud, Dominique S Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title | Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title_full | Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title_fullStr | Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title_full_unstemmed | Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title_short | Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts |
title_sort | circulating igg antibodies to periodontal bacteria and lung cancer risk in the clue cohorts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152995/ https://www.ncbi.nlm.nih.gov/pubmed/37040077 http://dx.doi.org/10.1093/jncics/pkad029 |
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