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Discovery and Validation of Novel LonP1 and Proteasome Inhibitor in IDH1-R132H Malignant Astrocytoma Models

Malignant astrocytomas are aggressive glioma tumors that have poor prognosis and limited treatments available following recurrence. These tumors are characterized by extensive hypoxia-induced, mitochondria-dependent changes such as glycolytic respiration, increased chymotrypsin-like (CT-L) proteasom...

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Detalles Bibliográficos
Autores principales:	Douglas, Christopher, Lomeli, Naomi, Lepe, Javier, Di, Kaijun, Nandwana, Nitesh Kumar, Vu, Thao, Pham, James, Kenney, Maria Cristina, Das, Bhaskar, Bota, Daniela A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153114/ https://www.ncbi.nlm.nih.gov/pubmed/37131786 http://dx.doi.org/10.1101/2023.04.13.536816

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