CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers

Somatic mutations are desirable targets for selective elimination of cancer, yet most are found within the noncoding regions. We propose a novel, cancer-specific killing approach using CRISPR-Cas9 which exploits the requirement of a protospacer adjacent motif (PAM) for Cas9 activity. Through whole g...

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Detalles Bibliográficos
Autores principales: Teh, Selina Shiqing K., Bowland, Kirsten, Bennett, Alexis, Halper-Stromberg, Eitan, Skaist, Alyza, Tang, Jacqueline, Cai, Fidel, Macoretta, Antonella, Liang, Hong, Kamiyama, Hirohiko, Wheelan, Sarah, Lin, Ming-Tseh, Hruban, Ralph H., Scharpf, Robert B., Roberts, Nicholas J., Eshleman, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153132/
https://www.ncbi.nlm.nih.gov/pubmed/37131822
http://dx.doi.org/10.1101/2023.04.15.537042

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