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MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure

BACKGROUND: Mitochondrial calcium ((m)Ca(2+)) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessive (m)Ca(2+) uptake during stress, as in ischemia-reperfusion, initiates permeability transition and...

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Detalles Bibliográficos
Autores principales:	Garbincius, Joanne F., Luongo, Timothy S., Lambert, Jonathan P., Mangold, Adam S., Murray, Emma K., Hildebrand, Alycia N., Jadiya, Pooja, Elrod, John W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153142/ https://www.ncbi.nlm.nih.gov/pubmed/37131819 http://dx.doi.org/10.1101/2023.04.17.537222

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