A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs

Age is a major risk factor for lung disease. To understand the mechanisms underlying this association, we characterized the changing cellular, genomic, transcriptional, and epigenetic landscape of lung aging using bulk and single-cell RNAseq (scRNAseq) data. Our analysis revealed age-associated gene...

Descripción completa

Detalles Bibliográficos
Autores principales: De Man, Ruben, McDonough, John E, Adams, Taylor S, Manning, Edward P, Myers, Greg, Vos, Robin, Ceulemans, Laurens, Dupont, Lieven, Vanaudenaerde, Bart M, Wuyts, Wim A, Rosas, Ivan O, Hagood, James S., Ambalavanan, Namasivayam, Niklason, Laura, Hansen, Kirk C, Yan, Xiting, Kaminski, Naftali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153177/
https://www.ncbi.nlm.nih.gov/pubmed/37131739
http://dx.doi.org/10.1101/2023.04.19.536722

Ejemplares similares

Ejemplares similares