Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics

The heritability explained by local ancestry markers in an admixed population [Formula: see text] provides crucial insight into the genetic architecture of a complex disease or trait. Estimation of [Formula: see text] can be susceptible to biases due to population structure in ancestral populations....

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Detalles Bibliográficos
Autores principales: Chan, Tsz Fung, Rui, Xinyue, Conti, David V., Fornage, Myriam, Graff, Mariaelisa, Haessler, Jeffrey, Haiman, Christopher, Highland, Heather M., Jung, Su Yon, Kenny, Eimear, Kooperberg, Charles, Marchland, Loic Le, North, Kari E., Tao, Ran, Wojcik, Genevieve, Gignoux, Christopher R., Chiang, Charleston W. K., Mancuso, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153181/
https://www.ncbi.nlm.nih.gov/pubmed/37131817
http://dx.doi.org/10.1101/2023.04.10.536252

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