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From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses
Noninvasive techniques to record and stimulate the brain rely on passing through the tissues in between the scalp and cortex. Currently, there is no method to obtain detailed information about these scalp-to-cortex distance (SCD) tissues. We introduce GetTissueThickness (GTT), an open-source, automa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153183/ https://www.ncbi.nlm.nih.gov/pubmed/37131842 http://dx.doi.org/10.1101/2023.04.18.537177 |
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author | Van Hoornweder, Sybren Geraerts, Marc Verstraelen, Stefanie Nuyts, Marten Caulfield, Kevin A. Meesen, Raf |
author_facet | Van Hoornweder, Sybren Geraerts, Marc Verstraelen, Stefanie Nuyts, Marten Caulfield, Kevin A. Meesen, Raf |
author_sort | Van Hoornweder, Sybren |
collection | PubMed |
description | Noninvasive techniques to record and stimulate the brain rely on passing through the tissues in between the scalp and cortex. Currently, there is no method to obtain detailed information about these scalp-to-cortex distance (SCD) tissues. We introduce GetTissueThickness (GTT), an open-source, automated approach to quantify SCD, and unveil how tissue thicknesses differ across age groups, sexes and brain regions (n = 250). We show that men have larger SCD in lower scalp regions and women have similar-to-larger SCD in regions closer to the vertex, with aging resulting in increased SCD in fronto-central regions. Soft tissue thickness varies by sex and age, with thicker layers and greater age-related decreases in men. Compact and spongy bone thickness also differ across sexes and age groups, with thicker compact bone in women in both age groups and an age-related thickening. Older men generally have the thickest cerebrospinal fluid layer and younger women and men having similar cerebrospinal fluid layers. Aging mostly results in grey matter thinning. Concerning SCD, the whole isn’t greater than the sum of its parts. GTT enables rapid quantification of the SCD tissues. The distinctive sensitivity of noninvasive recording and stimulation modalities to different tissues underscores the relevance of GTT. |
format | Online Article Text |
id | pubmed-10153183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-101531832023-05-03 From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses Van Hoornweder, Sybren Geraerts, Marc Verstraelen, Stefanie Nuyts, Marten Caulfield, Kevin A. Meesen, Raf bioRxiv Article Noninvasive techniques to record and stimulate the brain rely on passing through the tissues in between the scalp and cortex. Currently, there is no method to obtain detailed information about these scalp-to-cortex distance (SCD) tissues. We introduce GetTissueThickness (GTT), an open-source, automated approach to quantify SCD, and unveil how tissue thicknesses differ across age groups, sexes and brain regions (n = 250). We show that men have larger SCD in lower scalp regions and women have similar-to-larger SCD in regions closer to the vertex, with aging resulting in increased SCD in fronto-central regions. Soft tissue thickness varies by sex and age, with thicker layers and greater age-related decreases in men. Compact and spongy bone thickness also differ across sexes and age groups, with thicker compact bone in women in both age groups and an age-related thickening. Older men generally have the thickest cerebrospinal fluid layer and younger women and men having similar cerebrospinal fluid layers. Aging mostly results in grey matter thinning. Concerning SCD, the whole isn’t greater than the sum of its parts. GTT enables rapid quantification of the SCD tissues. The distinctive sensitivity of noninvasive recording and stimulation modalities to different tissues underscores the relevance of GTT. Cold Spring Harbor Laboratory 2023-04-19 /pmc/articles/PMC10153183/ /pubmed/37131842 http://dx.doi.org/10.1101/2023.04.18.537177 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Van Hoornweder, Sybren Geraerts, Marc Verstraelen, Stefanie Nuyts, Marten Caulfield, Kevin A. Meesen, Raf From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title | From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title_full | From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title_fullStr | From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title_full_unstemmed | From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title_short | From scalp to cortex, the whole isn’t greater than the sum of its parts: introducing GetTissueThickness (GTT) to assess age and sex differences in tissue thicknesses |
title_sort | from scalp to cortex, the whole isn’t greater than the sum of its parts: introducing gettissuethickness (gtt) to assess age and sex differences in tissue thicknesses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153183/ https://www.ncbi.nlm.nih.gov/pubmed/37131842 http://dx.doi.org/10.1101/2023.04.18.537177 |
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