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Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging
Aggregation of amyloid beta (Aβ) peptides into extracellular plaques is a hallmark of the molecular pathology of Alzheimer’s disease (AD). Amyloid aggregates have been extensively studied in-vitro, and it is well known that mature amyloid fibrils contain an ordered parallel β structure. The structur...
Autores principales: | Holcombe, Brooke, Foes, Abigail, Banerjee, Siddhartha, Yeh, Kevin, Wang, Shih-Hsiu J., Bhargava, Rohit, Ghosh, Ayanjeet |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153194/ https://www.ncbi.nlm.nih.gov/pubmed/37131832 http://dx.doi.org/10.1101/2023.04.18.537414 |
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