Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency

Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, and neuronal ceroid lipofuscinosis. Proper PGRN levels are critical to maintain brain health and neuronal survival, however the function of PGRN is not w...

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Detalles Bibliográficos
Autores principales: Root, Jessica, Mendsaikhan, Anarmaa, Nandy, Srijita, Taylor, Georgia, Wang, Minzheng, Araujo, Ludmilla Troiano, Merino, Paola, Ryu, Danny, Holler, Christopher, Thompson, Bonne M., Astarita, Giuseppe, Blain, Jean-François, Kukar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153205/
https://www.ncbi.nlm.nih.gov/pubmed/37131734
http://dx.doi.org/10.1101/2023.04.17.536004

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