Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection

SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on receptor binding domain changes, mutations in the C-terminus of S1 (CTS1), adjacent to the furin cleavage site, have largely been ignored. In this study, we exam...

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Detalles Bibliográficos
Autores principales: Vu, Michelle N., Alvarado, R. Elias, Morris, Dorothea R., Lokugamage, Kumari G., Zhou, Yiyang, Morgan, Angelica L., Estes, Leah K., McLeland, Alyssa M., Schindewolf, Craig, Plante, Jessica A., Ahearn, Yani P., Meyers, William M., Murray, Jordan T., Crocquet-Valdes, Patricia A., Weaver, Scott C., Walker, David H., Russell, William K., Routh, Andrew L., Plante, Kenneth S., Menachery, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153209/
https://www.ncbi.nlm.nih.gov/pubmed/37131784
http://dx.doi.org/10.1101/2023.04.17.536926

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