Cargando…
Alterations in cortical excitability during pain: A combined TMS-EEG Study
Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain and in chronic pain populations. However, current applications of TMS to pain have been restricted to measurements of motor evoked potentials (MEPs) from peripheral muscles....
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153239/ https://www.ncbi.nlm.nih.gov/pubmed/37131586 http://dx.doi.org/10.1101/2023.04.20.537735 |
_version_ | 1785035893604614144 |
---|---|
author | Chowdhury, Nahian S Chiang, Alan KI Millard, Samantha K Skippen, Patrick Chang, Wei-Ju Seminowicz, David A Schabrun, Siobhan M |
author_facet | Chowdhury, Nahian S Chiang, Alan KI Millard, Samantha K Skippen, Patrick Chang, Wei-Ju Seminowicz, David A Schabrun, Siobhan M |
author_sort | Chowdhury, Nahian S |
collection | PubMed |
description | Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain and in chronic pain populations. However, current applications of TMS to pain have been restricted to measurements of motor evoked potentials (MEPs) from peripheral muscles. Here, TMS was combined with electroencephalography (EEG) to determine whether experimental pain could induce alterations in cortical inhibitory/facilitatory activity observed in TMS-evoked potentials (TEPs). In Experiment 1 (n = 29), multiple sustained thermal stimuli were administered to the forearm, with the first, second and third block of thermal stimuli consisting of warm but non-painful (pre-pain block), painful (pain block) and warm but non-painful (post-pain block) temperatures respectively. During each stimulus, TMS pulses were delivered while EEG (64 channels) was simultaneously recorded. Verbal pain ratings were collected between TMS pulses. Relative to pre-pain warm stimuli, painful stimuli led to an increase in the amplitude of the frontocentral negative peak ~45ms post-TMS (N45), with a larger increase associated with higher pain ratings. Experiments 2 and 3 (n = 10 in each) showed that the increase in the N45 in response to pain was not due to changes in sensory potentials associated with TMS, or a result of stronger reafferent muscle feedback during pain. This is the first study to use combined TMS-EEG to examine alterations in cortical excitability in response to pain. These results suggest that the N45 TEP peak, which indexes GABAergic neurotransmission, is implicated in pain perception and is a potential marker of individual differences in pain sensitivity. |
format | Online Article Text |
id | pubmed-10153239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-101532392023-05-03 Alterations in cortical excitability during pain: A combined TMS-EEG Study Chowdhury, Nahian S Chiang, Alan KI Millard, Samantha K Skippen, Patrick Chang, Wei-Ju Seminowicz, David A Schabrun, Siobhan M bioRxiv Article Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain and in chronic pain populations. However, current applications of TMS to pain have been restricted to measurements of motor evoked potentials (MEPs) from peripheral muscles. Here, TMS was combined with electroencephalography (EEG) to determine whether experimental pain could induce alterations in cortical inhibitory/facilitatory activity observed in TMS-evoked potentials (TEPs). In Experiment 1 (n = 29), multiple sustained thermal stimuli were administered to the forearm, with the first, second and third block of thermal stimuli consisting of warm but non-painful (pre-pain block), painful (pain block) and warm but non-painful (post-pain block) temperatures respectively. During each stimulus, TMS pulses were delivered while EEG (64 channels) was simultaneously recorded. Verbal pain ratings were collected between TMS pulses. Relative to pre-pain warm stimuli, painful stimuli led to an increase in the amplitude of the frontocentral negative peak ~45ms post-TMS (N45), with a larger increase associated with higher pain ratings. Experiments 2 and 3 (n = 10 in each) showed that the increase in the N45 in response to pain was not due to changes in sensory potentials associated with TMS, or a result of stronger reafferent muscle feedback during pain. This is the first study to use combined TMS-EEG to examine alterations in cortical excitability in response to pain. These results suggest that the N45 TEP peak, which indexes GABAergic neurotransmission, is implicated in pain perception and is a potential marker of individual differences in pain sensitivity. Cold Spring Harbor Laboratory 2023-08-07 /pmc/articles/PMC10153239/ /pubmed/37131586 http://dx.doi.org/10.1101/2023.04.20.537735 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Chowdhury, Nahian S Chiang, Alan KI Millard, Samantha K Skippen, Patrick Chang, Wei-Ju Seminowicz, David A Schabrun, Siobhan M Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title | Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title_full | Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title_fullStr | Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title_full_unstemmed | Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title_short | Alterations in cortical excitability during pain: A combined TMS-EEG Study |
title_sort | alterations in cortical excitability during pain: a combined tms-eeg study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153239/ https://www.ncbi.nlm.nih.gov/pubmed/37131586 http://dx.doi.org/10.1101/2023.04.20.537735 |
work_keys_str_mv | AT chowdhurynahians alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT chiangalanki alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT millardsamanthak alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT skippenpatrick alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT changweiju alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT seminowiczdavida alterationsincorticalexcitabilityduringpainacombinedtmseegstudy AT schabrunsiobhanm alterationsincorticalexcitabilityduringpainacombinedtmseegstudy |