Identifying antisense oligonucleotides to disrupt small RNA regulated antibiotic resistance via a cell-free transcription-translation platform

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Bacterial small RNAs (sRNAs) regulate many important physiological processes in cells including antibiotic resistance and virulence genes through base pairing interactions with mRNAs. Antisense oligonucleotides (ASOs) have great potential as therapeutics against bacterial pathogens by targeting sRNA...

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Detalles Bibliográficos
Autores principales: Tsai, Min Jen, Zambrano, Raphael Angelo I., Susas, Jeremiah Lyn, Silva, Lizette, Takahashi, Melissa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153260/
https://www.ncbi.nlm.nih.gov/pubmed/37131760
http://dx.doi.org/10.1101/2023.04.19.537543
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