Antibody Correlates of Protection for COVID-19 Convalescent Plasma Associated with Reduced Outpatient Hospitalizations

SARS-CoV-2 antibody levels associated with reduced hospitalization risk remain undefined. Our outpatient COVID-19 convalescent plasma (CCP), placebo-controlled trial observed SARS-CoV-2 antibody levels decreasing 22-fold from matched donor units into post-transfusion seronegative recipients. Unvacci...

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Detalles Bibliográficos
Autores principales: Park, Han-Sol, Barranta, Caelan, Yin, Anna, Lee, John S., Caputo, Christopher A., Li, Maggie, Yoon, Steve, Sitaras, Ioannis, Jedlicka, Anne, Eby, Yolanda, Ram, Malathi, Fernandez, Reinaldo E., Baker, Owen R., Shenoy, Aarthi G., Mosnaim, Giselle S., Fukuta, Yuriko, Patel, Bela, Heath, Sonya L., Levine, Adam C., Meisenberg, Barry R., Spivak, Emily S., Anjan, Shweta, Huaman, Moises A., Blair, Janis E., Currier, Judith S., Paxton, James H., Gerber, Jonathan M., Petrini, Joann R., Broderick, Patrick B., Rausch, William, Cordisco, Marie Elena, Hammel, Jean, Greenblatt, Benjamin, Cluzet, Valerie C., Cruser, Daniel, Oei, Kevin, Abinante, Matthew, Hammitt, Laura L., Sutcliffe, Catherine G., Forthal, Donald N., Zand, Martin S., Cachay, Edward R., Raval, Jay S., Kassaye, Seble G., Marshall, Christi E., Yarava, Anusha, Lane, Karen, McBee, Nichol A., Gawad, Amy L., Karlen, Nicky, Singh, Atika, Ford, Daniel E., Jabs, Douglas A., Appel, Lawrence J., Shade, David M., Lau, Bryan, Ehrhardt, Stephan, Baksh, Sheriza N., Shapiro, Janna R., Ou, Jiangda, Gniadek, Thomas J., Caturegli, Patrizio, Wu, Jinke, Ndahiro, Nelson, Betenbaugh, Michael J., Ziman, Alyssa, Hanley, Daniel F., Casadevall, Arturo, Shoham, Shmuel, Bloch, Evan M., Gebo, Kelly A., Tobian, Aaron A.R., Laeyendecker, Oliver, Pekosz, Andrew, Klein, Sabra L., Sullivan, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153328/
https://www.ncbi.nlm.nih.gov/pubmed/37131659
http://dx.doi.org/10.1101/2023.04.13.23288353

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