Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies

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Invasion of human red blood cells (RBCs) by Plasmodium falciparum (Pf) merozoites relies on the interaction between two parasite proteins, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2)(1,2). Antibodies to AMA1 confer limited protection against P. falciparum in non-human primate...

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Detalles Bibliográficos
Autores principales: Srinivasan, Prakash, Yanik, Sean, Venkatesh, Varsha, Parker, Michelle, Diouf, Ababacar, Sarkar, Deepti, Miura, Kazutoyo, Long, Carole, Boulanger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153359/
https://www.ncbi.nlm.nih.gov/pubmed/37131813
http://dx.doi.org/10.21203/rs.3.rs-2733434/v1
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