Computational modeling and synthesis of Pyridine variants of Benzoyl-Phenoxy-Acetamide with high glioblastoma cytotoxicity and brain tumor penetration

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Glioblastomas are highly aggressive brain tumors for which therapeutic options are very limited. In a quest for new anti-glioblastoma drugs, we focused on specific structural modifications of benzoyl-phenoxy-acetamide (BPA) present in a common lipid-lowering drug, fenofibrate, and in our first proto...

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Detalles Bibliográficos
Autores principales: Ingraham IV, Charles, Stalinska, Joanna, Carson, Sean, Colley, Susan, Rak, Monika, Lassak, Adam, Reiss, Krzysztof, Jursic, Branko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153368/
https://www.ncbi.nlm.nih.gov/pubmed/37131829
http://dx.doi.org/10.21203/rs.3.rs-2773503/v1

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