ERK Hyperactivation Serves as a Unified Mechanism of Escape in Intrinsic and Acquired CDK4/6 Inhibitor Resistance in Acral Lentiginous Melanoma

Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of cutaneous melanoma (CM), and do not benefit as well to approved melanoma therapies. Identification of cyclin-dependent kinase 4 and 6 (CDK4/6) pathway gene alterations in > 60%...

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Detalles Bibliográficos
Autores principales: Rebecca, Vito, Jagirdar, Kasturee, Portuallo, Marie, Wei, Meihan, Wilhide, Matthew, Bravo, Jeremy, Robertson, Bailey, Alicea, Gretchen, Aguh, Crsytal, Xiao, Min, Godok, Tetiana, Fingerman, Dylan, Brown, Gregory, Herlyn, Meenhard, Guo, Brian, Toska, Eneda, Zabransky, Daniel, Wubbenhorst, Bradley, Nathanson, Katherine, Kwatra, Shawn, Goyal, Yogesh, Ji, Hongkai, Liu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153386/
https://www.ncbi.nlm.nih.gov/pubmed/37131684
http://dx.doi.org/10.21203/rs.3.rs-2817876/v1

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