Elucidation of the genetic causes of bicuspid aortic valve disease

AIMS: The present study aims to characterize the genetic risk architecture of bicuspid aortic valve (BAV) disease, the most common congenital heart defect. METHODS AND RESULTS: We carried out a genome-wide association study (GWAS) including 2236 BAV patients and 11 604 controls. This led to the iden...

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Detalles Bibliográficos
Autores principales: Gehlen, Jan, Stundl, Anja, Debiec, Radoslaw, Fontana, Federica, Krane, Markus, Sharipova, Dinara, Nelson, Christopher P, Al-Kassou, Baravan, Giel, Ann-Sophie, Sinning, Jan-Malte, Bruenger, Christopher M H, Zelck, Carolin F, Koebbe, Laura L, Braund, Peter S, Webb, Thomas R, Hetherington, Simon, Ensminger, Stephan, Fujita, Buntaro, Mohamed, Salah A, Shrestha, Malakh, Krueger, Heike, Siepe, Matthias, Kari, Fabian Alexander, Nordbeck, Peter, Buravezky, Larissa, Kelm, Malte, Veulemans, Verena, Adam, Matti, Baldus, Stephan, Laugwitz, Karl-Ludwig, Haas, Yannick, Karck, Matthias, Mehlhorn, Uwe, Conzelmann, Lars Oliver, Breitenbach, Ingo, Lebherz, Corinna, Urbanski, Paul, Kim, Won-Keun, Kandels, Joscha, Ellinghaus, David, Nowak-Goettl, Ulrike, Hoffmann, Per, Wirth, Felix, Doppler, Stefanie, Lahm, Harald, Dreßen, Martina, von Scheidt, Moritz, Knoll, Katharina, Kessler, Thorsten, Hengstenberg, Christian, Schunkert, Heribert, Nickenig, Georg, Nöthen, Markus M, Bolger, Aidan P, Abdelilah-Seyfried, Salim, Samani, Nilesh J, Erdmann, Jeanette, Trenkwalder, Teresa, Schumacher, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153415/
https://www.ncbi.nlm.nih.gov/pubmed/35727948
http://dx.doi.org/10.1093/cvr/cvac099

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