Impaired regulation of MMP2/16–MLCK3 by miR-146a-5p increased susceptibility to myocardial ischaemic injury in aging mice

AIMS: Aging impairs cardiac function and increases susceptibility to myocardial ischaemic injury. Cardiac myosin light chain kinase (MLCK3) phosphorylates cardiac myosin regulatory light chain (MLC2), controlling sarcomere organization and cardiomyocyte contraction. Dysregulation of MLCK3 and phosph...

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Detalles Bibliográficos
Autores principales: Dong, Ming, Chen, Dishen, Zhu, Yanxia, Yang, Shu, Kumar, Santosh, Zhang, Rui, Zhou, Yin, Yang, Ziyi, Zheng, Na, Zhu, Ting, Xiang, Jiaqing, Liu, Yun, Kang, Lin, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153423/
https://www.ncbi.nlm.nih.gov/pubmed/35727952
http://dx.doi.org/10.1093/cvr/cvac104

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