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SARS-CoV-2 N Protein Triggers Acute Lung Injury via Modulating Macrophage Activation and Infiltration in in vitro and in vivo

BACKGROUND: SARS-CoV-2-induced acute lung injury but its nucleocapsid (N) and/or Spike (S) protein involvements in the disease pathology remain elusive. METHODS: In vitro, the cultured THP-1 macrophages were stimulated with alive SARS-CoV-2 virus at different loading dose, N protein or S protein wit...

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Detalles Bibliográficos
Autores principales:	Lai, Dengming, Zhu, Kun, Li, Sisi, Xiao, Yi, Xu, Qi, Sun, Yisheng, Yao, Pingping, Ma, Daqing, Shu, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153437/ https://www.ncbi.nlm.nih.gov/pubmed/37143821 http://dx.doi.org/10.2147/JIR.S405722

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