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Facing Antitubercular Resistance: Identification of Potential Direct Inhibitors Targeting InhA Enzyme and Generation of 3D-pharmacophore Model by in silico Approach

PURPOSE: The enoyl-acyl carrier protein reductase (InhA) is one of the important key enzymes employed in mycolic acids biosynthesis pathway and an important component of mycobacterial cell walls. This enzyme has also been identified as major target of isoniazid drug, except that isoniazid needs to b...

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Detalles Bibliográficos
Autores principales:	EL Haddoumi, Ghyzlane, Mansouri, Mariam, Bendani, Houda, Bouricha, El Mehdi, Kandoussi, Ilham, Belyamani, Lahcen, Ibrahimi, Azeddine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153438/ https://www.ncbi.nlm.nih.gov/pubmed/37143606 http://dx.doi.org/10.2147/AABC.S394535

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