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A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements

The somatic hypermutation (SHM) status of the clonotypic, rearranged immunoglobulin heavy variable (IGHV) gene is an established prognostic and predictive marker in chronic lymphocytic leukemia (CLL). Analysis of SHM is generally performed by polymerase chain reaction (PCR)-amplification of clonal I...

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Detalles Bibliográficos
Autores principales:	McCafferty, Neil, Stewart, James Peter, Darzentas, Nikos, Gazdova, Jana, Catherwood, Mark, Stamatopoulos, Kostas, Langerak, Anton W., Gonzalez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2022
Materias:	Article - Chronic Lymphocytic Leukemia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153525/ https://www.ncbi.nlm.nih.gov/pubmed/36579446 http://dx.doi.org/10.3324/haematol.2022.281928

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