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Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia

A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the receptor tyrosine kinase Fms-like receptor tyrosine kinase 3 (FLT3) upregulated by cooperation...

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Detalles Bibliográficos
Autores principales:	Sahoo, Binay K., Lin, Yuh-Charn, Tu, Cheng-Fen, Lin, Chien-Chin, Liao, Wei-Ju, Li, Fu-An, Li, Ling-Hui, Mou, Kurt Yun, Roffler, Steve R., Wang, Shu-Ping, Yeh, Chi-Tai, Yao, Chi-Yuan, Hou, Hsin-An, Chou, Wen-Chien, Tien, Hwei-Fang, Yang, Ruey-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2022
Materias:	ARTICLE - Acute Myeloid Leukemia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153537/ https://www.ncbi.nlm.nih.gov/pubmed/36005562 http://dx.doi.org/10.3324/haematol.2022.281151

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