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IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject...

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Autores principales: Ostrin, Lisa A., Harb, Elise, Nickla, Debora L., Read, Scott A., Alonso-Caneiro, David, Schroedl, Falk, Kaser-Eichberger, Alexandra, Zhou, Xiangtian, Wildsoet, Christine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153586/
https://www.ncbi.nlm.nih.gov/pubmed/37126359
http://dx.doi.org/10.1167/iovs.64.6.4
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author Ostrin, Lisa A.
Harb, Elise
Nickla, Debora L.
Read, Scott A.
Alonso-Caneiro, David
Schroedl, Falk
Kaser-Eichberger, Alexandra
Zhou, Xiangtian
Wildsoet, Christine F.
author_facet Ostrin, Lisa A.
Harb, Elise
Nickla, Debora L.
Read, Scott A.
Alonso-Caneiro, David
Schroedl, Falk
Kaser-Eichberger, Alexandra
Zhou, Xiangtian
Wildsoet, Christine F.
author_sort Ostrin, Lisa A.
collection PubMed
description The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient.
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spelling pubmed-101535862023-05-03 IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia Ostrin, Lisa A. Harb, Elise Nickla, Debora L. Read, Scott A. Alonso-Caneiro, David Schroedl, Falk Kaser-Eichberger, Alexandra Zhou, Xiangtian Wildsoet, Christine F. Invest Ophthalmol Vis Sci Special Issue The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient. The Association for Research in Vision and Ophthalmology 2023-05-01 /pmc/articles/PMC10153586/ /pubmed/37126359 http://dx.doi.org/10.1167/iovs.64.6.4 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Special Issue
Ostrin, Lisa A.
Harb, Elise
Nickla, Debora L.
Read, Scott A.
Alonso-Caneiro, David
Schroedl, Falk
Kaser-Eichberger, Alexandra
Zhou, Xiangtian
Wildsoet, Christine F.
IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title_full IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title_fullStr IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title_full_unstemmed IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title_short IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
title_sort imi—the dynamic choroid: new insights, challenges, and potential significance for human myopia
topic Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153586/
https://www.ncbi.nlm.nih.gov/pubmed/37126359
http://dx.doi.org/10.1167/iovs.64.6.4
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