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Targeting immune cell trafficking and vascular endothelial cells in psoriasis

The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting imm...

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Detalles Bibliográficos
Autores principales: Young, Kelly Z., Plazyo, Olesya, Gudjonsson, Johann E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153674/
https://www.ncbi.nlm.nih.gov/pubmed/37115692
http://dx.doi.org/10.1172/JCI169450
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author Young, Kelly Z.
Plazyo, Olesya
Gudjonsson, Johann E.
author_facet Young, Kelly Z.
Plazyo, Olesya
Gudjonsson, Johann E.
author_sort Young, Kelly Z.
collection PubMed
description The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting immune cells to specific areas of vascular damage, infection, or foreign material. However, mechanisms through which ECs participate in immune-mediated responses remain to be fully explored. In this issue of the JCI, Li, Shao, et al. report on vascular endothelial glycocalyx destruction and the mechanisms through which EC dysfunction contributes to the well-characterized immune-mediated features of psoriasis, a chronic inflammatory skin disease. Here, we discuss the implications of these findings and highlight some risks and benefits of existing therapies designed to target immune cell trafficking in a variety of inflammatory conditions.
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spelling pubmed-101536742023-05-03 Targeting immune cell trafficking and vascular endothelial cells in psoriasis Young, Kelly Z. Plazyo, Olesya Gudjonsson, Johann E. J Clin Invest Commentary The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting immune cells to specific areas of vascular damage, infection, or foreign material. However, mechanisms through which ECs participate in immune-mediated responses remain to be fully explored. In this issue of the JCI, Li, Shao, et al. report on vascular endothelial glycocalyx destruction and the mechanisms through which EC dysfunction contributes to the well-characterized immune-mediated features of psoriasis, a chronic inflammatory skin disease. Here, we discuss the implications of these findings and highlight some risks and benefits of existing therapies designed to target immune cell trafficking in a variety of inflammatory conditions. American Society for Clinical Investigation 2023-05-01 /pmc/articles/PMC10153674/ /pubmed/37115692 http://dx.doi.org/10.1172/JCI169450 Text en © 2023 Young et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Young, Kelly Z.
Plazyo, Olesya
Gudjonsson, Johann E.
Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title_full Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title_fullStr Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title_full_unstemmed Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title_short Targeting immune cell trafficking and vascular endothelial cells in psoriasis
title_sort targeting immune cell trafficking and vascular endothelial cells in psoriasis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153674/
https://www.ncbi.nlm.nih.gov/pubmed/37115692
http://dx.doi.org/10.1172/JCI169450
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