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Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery

Mitochondrial decline is a key feature of ageing. The retina has more mitochondria than any other tissue and ages rapidly. To understand human retinal ageing it is critical to examine old world primates that have similar visual systems to humans, and do so across central and peripheral regions, as t...

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Autores principales: Kam, Jaimie Hoh, Shinhmar, Harpreet, Powner, Michael Barry, Hayes, Matthew John, Aboelnour, Asmaa, Jeffery, Glen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153720/
https://www.ncbi.nlm.nih.gov/pubmed/37130143
http://dx.doi.org/10.1371/journal.pone.0273882
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author Kam, Jaimie Hoh
Shinhmar, Harpreet
Powner, Michael Barry
Hayes, Matthew John
Aboelnour, Asmaa
Jeffery, Glen
author_facet Kam, Jaimie Hoh
Shinhmar, Harpreet
Powner, Michael Barry
Hayes, Matthew John
Aboelnour, Asmaa
Jeffery, Glen
author_sort Kam, Jaimie Hoh
collection PubMed
description Mitochondrial decline is a key feature of ageing. The retina has more mitochondria than any other tissue and ages rapidly. To understand human retinal ageing it is critical to examine old world primates that have similar visual systems to humans, and do so across central and peripheral regions, as there is evidence for early central decline. Hence, we examine mitochondrial metrics in young and ageing Macaca fascicularis retinae. In spite of reduced ATP with age, primate mitochondrial complex activity did not decline. But mitochondrial membrane potentials were reduced significantly, and concomitantly, mitochondrial membrane permeability increased. The mitochondrial marker Tom20 declined significantly, consistent with reduced mitochondria number, while VDAC, a voltage dependent anion channel and diffusion pore associated with apoptosis increased significantly. In spite of these clear age-related changes, there was almost no evidence for regional differences between the centre and the periphery in these mitochondrial metrics. Primate cones do not die with age, but many showed marked structural decline with vacuous spaces in proximal inner segments normally occupied by endoplasmic reticulum (ER), that regulate mitochondrial autophagy. In many peripheral cones, ER was displaced by the nucleus that transposed across the outer limiting membrane and could become embedded in mitochondrial populations. These data are consistent with significant changes in retinal mitochondria in old world primate ageing but provide little if any evidence that aged central mitochondria suffer more than those in the periphery.
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spelling pubmed-101537202023-05-03 Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery Kam, Jaimie Hoh Shinhmar, Harpreet Powner, Michael Barry Hayes, Matthew John Aboelnour, Asmaa Jeffery, Glen PLoS One Research Article Mitochondrial decline is a key feature of ageing. The retina has more mitochondria than any other tissue and ages rapidly. To understand human retinal ageing it is critical to examine old world primates that have similar visual systems to humans, and do so across central and peripheral regions, as there is evidence for early central decline. Hence, we examine mitochondrial metrics in young and ageing Macaca fascicularis retinae. In spite of reduced ATP with age, primate mitochondrial complex activity did not decline. But mitochondrial membrane potentials were reduced significantly, and concomitantly, mitochondrial membrane permeability increased. The mitochondrial marker Tom20 declined significantly, consistent with reduced mitochondria number, while VDAC, a voltage dependent anion channel and diffusion pore associated with apoptosis increased significantly. In spite of these clear age-related changes, there was almost no evidence for regional differences between the centre and the periphery in these mitochondrial metrics. Primate cones do not die with age, but many showed marked structural decline with vacuous spaces in proximal inner segments normally occupied by endoplasmic reticulum (ER), that regulate mitochondrial autophagy. In many peripheral cones, ER was displaced by the nucleus that transposed across the outer limiting membrane and could become embedded in mitochondrial populations. These data are consistent with significant changes in retinal mitochondria in old world primate ageing but provide little if any evidence that aged central mitochondria suffer more than those in the periphery. Public Library of Science 2023-05-02 /pmc/articles/PMC10153720/ /pubmed/37130143 http://dx.doi.org/10.1371/journal.pone.0273882 Text en © 2023 Kam et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kam, Jaimie Hoh
Shinhmar, Harpreet
Powner, Michael Barry
Hayes, Matthew John
Aboelnour, Asmaa
Jeffery, Glen
Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title_full Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title_fullStr Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title_full_unstemmed Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title_short Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
title_sort mitochondrial decline in the ageing old world primate retina: little evidence for difference between the centre and periphery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153720/
https://www.ncbi.nlm.nih.gov/pubmed/37130143
http://dx.doi.org/10.1371/journal.pone.0273882
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