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Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens

The pre-axial border medially moves between the fetal and early postnatal periods, and the foot sole can be placed on the ground. Nonetheless, the precise timeline when this posture is achieved remains poorly understood. The hip joint is the most freely movable joint in the lower limbs and largely d...

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Autores principales: Takakuwa, Tetsuya, Saizonou, Marie Ange, Fujii, Sena, Kumano, Yousuke, Ishikawa, Aoi, Aoyama, Tomoki, Imai, Hirohiko, Yamada, Shigehito, Kanahashi, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153723/
https://www.ncbi.nlm.nih.gov/pubmed/37130112
http://dx.doi.org/10.1371/journal.pone.0285190
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author Takakuwa, Tetsuya
Saizonou, Marie Ange
Fujii, Sena
Kumano, Yousuke
Ishikawa, Aoi
Aoyama, Tomoki
Imai, Hirohiko
Yamada, Shigehito
Kanahashi, Toru
author_facet Takakuwa, Tetsuya
Saizonou, Marie Ange
Fujii, Sena
Kumano, Yousuke
Ishikawa, Aoi
Aoyama, Tomoki
Imai, Hirohiko
Yamada, Shigehito
Kanahashi, Toru
author_sort Takakuwa, Tetsuya
collection PubMed
description The pre-axial border medially moves between the fetal and early postnatal periods, and the foot sole can be placed on the ground. Nonetheless, the precise timeline when this posture is achieved remains poorly understood. The hip joint is the most freely movable joint in the lower limbs and largely determines the lower-limb posture. The present study aimed to establish a timeline of lower-limb development using a precise measurement of femoral posture. Magnetic resonance images of 157 human embryonic samples (Carnegie stages [CS] 19–23) and 18 fetal samples (crown rump length: 37.2–225 mm) from the Kyoto Collection were obtained. Three-dimensional coordinates of eight selected landmarks in the lower limbs and pelvis were used to calculate the femoral posture. Hip flexion was approximately 14° at CS19 and gradually increased to approximately 65° at CS23; the flexion angle ranged from 90° to 120° during the fetal period. Hip joint abduction was approximately 78° at CS19 and gradually decreased to approximately 27° at CS23; the average angle was approximately 13° during the fetal period. Lateral rotation was greater than 90° at CS19 and CS21 and decreased to approximately 65° at CS23; the average angle was approximately 43° during the fetal period. During the embryonic period, three posture parameters (namely, flexion, abduction, and lateral rotation of the hip) were linearly correlated with each other, suggesting that the femoral posture at each stage was three-dimensionally constant and exhibited gradual and smooth change according to growth. During the fetal period, these parameters varied among individuals, with no obvious trend. Our study has merits in that lengths and angles were measured on anatomical landmarks of the skeletal system. Our obtained data may contribute to understanding development from anatomical aspects and provide valuable insights for clinical application.
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spelling pubmed-101537232023-05-03 Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens Takakuwa, Tetsuya Saizonou, Marie Ange Fujii, Sena Kumano, Yousuke Ishikawa, Aoi Aoyama, Tomoki Imai, Hirohiko Yamada, Shigehito Kanahashi, Toru PLoS One Research Article The pre-axial border medially moves between the fetal and early postnatal periods, and the foot sole can be placed on the ground. Nonetheless, the precise timeline when this posture is achieved remains poorly understood. The hip joint is the most freely movable joint in the lower limbs and largely determines the lower-limb posture. The present study aimed to establish a timeline of lower-limb development using a precise measurement of femoral posture. Magnetic resonance images of 157 human embryonic samples (Carnegie stages [CS] 19–23) and 18 fetal samples (crown rump length: 37.2–225 mm) from the Kyoto Collection were obtained. Three-dimensional coordinates of eight selected landmarks in the lower limbs and pelvis were used to calculate the femoral posture. Hip flexion was approximately 14° at CS19 and gradually increased to approximately 65° at CS23; the flexion angle ranged from 90° to 120° during the fetal period. Hip joint abduction was approximately 78° at CS19 and gradually decreased to approximately 27° at CS23; the average angle was approximately 13° during the fetal period. Lateral rotation was greater than 90° at CS19 and CS21 and decreased to approximately 65° at CS23; the average angle was approximately 43° during the fetal period. During the embryonic period, three posture parameters (namely, flexion, abduction, and lateral rotation of the hip) were linearly correlated with each other, suggesting that the femoral posture at each stage was three-dimensionally constant and exhibited gradual and smooth change according to growth. During the fetal period, these parameters varied among individuals, with no obvious trend. Our study has merits in that lengths and angles were measured on anatomical landmarks of the skeletal system. Our obtained data may contribute to understanding development from anatomical aspects and provide valuable insights for clinical application. Public Library of Science 2023-05-02 /pmc/articles/PMC10153723/ /pubmed/37130112 http://dx.doi.org/10.1371/journal.pone.0285190 Text en © 2023 Takakuwa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Takakuwa, Tetsuya
Saizonou, Marie Ange
Fujii, Sena
Kumano, Yousuke
Ishikawa, Aoi
Aoyama, Tomoki
Imai, Hirohiko
Yamada, Shigehito
Kanahashi, Toru
Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title_full Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title_fullStr Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title_full_unstemmed Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title_short Femoral posture during embryonic and early fetal development: An analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
title_sort femoral posture during embryonic and early fetal development: an analysis using landmarks on the cartilaginous skeletons of ex vivo human specimens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153723/
https://www.ncbi.nlm.nih.gov/pubmed/37130112
http://dx.doi.org/10.1371/journal.pone.0285190
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