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Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes

OBJECTIVES: Pioglitazone (PIO) is a widely prescribed oral antidiabetic drug that has concerns regarding a potential risk of developing carcinoma of the urinary bladder. The objective of the current study was to assess this potential risk. MATERIALS AND METHODS: The potential risk of PIO-induced uri...

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Autores principales: Abdel-Hamid, Ahmed A. M., Firgany, Alaa El-Din L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153741/
https://www.ncbi.nlm.nih.gov/pubmed/37144164
http://dx.doi.org/10.4103/jmau.jmau_34_21
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author Abdel-Hamid, Ahmed A. M.
Firgany, Alaa El-Din L.
author_facet Abdel-Hamid, Ahmed A. M.
Firgany, Alaa El-Din L.
author_sort Abdel-Hamid, Ahmed A. M.
collection PubMed
description OBJECTIVES: Pioglitazone (PIO) is a widely prescribed oral antidiabetic drug that has concerns regarding a potential risk of developing carcinoma of the urinary bladder. The objective of the current study was to assess this potential risk. MATERIALS AND METHODS: The potential risk of PIO-induced urinary bladder carcinoma was assessed in the current study by examining urinary bladder of rats for urothelial cytokeratin (CK) expression and proliferative activity by Ki67 immunostaining. RESULTS: Histological examination revealed dysplastic urothelial changes in PIO per se and diabetes mellitus + PIO (diabetic rats receiving PIO). In addition, a significantly (P < 0.05) decreased CK7 and CK8 expression together with a significantly increased CK20 as well as Ki67 expression was detected in the urothelial cells of groups administrated PIO, contrary to those which did not. CONCLUSION: The manifestations of urothelial dysplasia evidenced by histological examination as well as by the aberrant expression in CK and Ki67 after PIO administration add supporting evidence at cellular and experimental level to the previous clinical suspicions.
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spelling pubmed-101537412023-05-03 Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes Abdel-Hamid, Ahmed A. M. Firgany, Alaa El-Din L. J Microsc Ultrastruct Original Article OBJECTIVES: Pioglitazone (PIO) is a widely prescribed oral antidiabetic drug that has concerns regarding a potential risk of developing carcinoma of the urinary bladder. The objective of the current study was to assess this potential risk. MATERIALS AND METHODS: The potential risk of PIO-induced urinary bladder carcinoma was assessed in the current study by examining urinary bladder of rats for urothelial cytokeratin (CK) expression and proliferative activity by Ki67 immunostaining. RESULTS: Histological examination revealed dysplastic urothelial changes in PIO per se and diabetes mellitus + PIO (diabetic rats receiving PIO). In addition, a significantly (P < 0.05) decreased CK7 and CK8 expression together with a significantly increased CK20 as well as Ki67 expression was detected in the urothelial cells of groups administrated PIO, contrary to those which did not. CONCLUSION: The manifestations of urothelial dysplasia evidenced by histological examination as well as by the aberrant expression in CK and Ki67 after PIO administration add supporting evidence at cellular and experimental level to the previous clinical suspicions. Wolters Kluwer - Medknow 2021-08-06 /pmc/articles/PMC10153741/ /pubmed/37144164 http://dx.doi.org/10.4103/jmau.jmau_34_21 Text en Copyright: © 2021 Journal of Microscopy and Ultrastructure https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Abdel-Hamid, Ahmed A. M.
Firgany, Alaa El-Din L.
Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title_full Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title_fullStr Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title_full_unstemmed Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title_short Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes
title_sort pioglitazone induces dysplastic urothelial changes in urinary bladder of experimental diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153741/
https://www.ncbi.nlm.nih.gov/pubmed/37144164
http://dx.doi.org/10.4103/jmau.jmau_34_21
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