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Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic

The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing scree...

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Autores principales: Nascimento de Lima, Pedro, van den Puttelaar, Rosita, Hahn, Anne I, Harlass, Matthias, Collier, Nicholson, Ozik, Jonathan, Zauber, Ann G, Lansdorp-Vogelaar, Iris, Rutter, Carolyn M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154022/
https://www.ncbi.nlm.nih.gov/pubmed/37129468
http://dx.doi.org/10.7554/eLife.85264
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author Nascimento de Lima, Pedro
van den Puttelaar, Rosita
Hahn, Anne I
Harlass, Matthias
Collier, Nicholson
Ozik, Jonathan
Zauber, Ann G
Lansdorp-Vogelaar, Iris
Rutter, Carolyn M
author_facet Nascimento de Lima, Pedro
van den Puttelaar, Rosita
Hahn, Anne I
Harlass, Matthias
Collier, Nicholson
Ozik, Jonathan
Zauber, Ann G
Lansdorp-Vogelaar, Iris
Rutter, Carolyn M
author_sort Nascimento de Lima, Pedro
collection PubMed
description The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation. The impact of these disruptions on long-term CRC outcomes was measured by the number of life-years lost due to CRC screening disruptions compared to a scenario without any disruptions. While short-term delays in screening of 3–18 months are predicted to result in minor life-years loss, discontinuing screening could result in much more significant reductions in the expected benefits of screening. These results demonstrate that unequal recovery of screening following the pandemic can widen disparities in CRC outcomes and emphasize the importance of ensuring equitable recovery to screening following the pandemic.
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spelling pubmed-101540222023-05-03 Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic Nascimento de Lima, Pedro van den Puttelaar, Rosita Hahn, Anne I Harlass, Matthias Collier, Nicholson Ozik, Jonathan Zauber, Ann G Lansdorp-Vogelaar, Iris Rutter, Carolyn M eLife Epidemiology and Global Health The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation. The impact of these disruptions on long-term CRC outcomes was measured by the number of life-years lost due to CRC screening disruptions compared to a scenario without any disruptions. While short-term delays in screening of 3–18 months are predicted to result in minor life-years loss, discontinuing screening could result in much more significant reductions in the expected benefits of screening. These results demonstrate that unequal recovery of screening following the pandemic can widen disparities in CRC outcomes and emphasize the importance of ensuring equitable recovery to screening following the pandemic. eLife Sciences Publications, Ltd 2023-05-02 /pmc/articles/PMC10154022/ /pubmed/37129468 http://dx.doi.org/10.7554/eLife.85264 Text en © 2023, Nascimento de Lima et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Nascimento de Lima, Pedro
van den Puttelaar, Rosita
Hahn, Anne I
Harlass, Matthias
Collier, Nicholson
Ozik, Jonathan
Zauber, Ann G
Lansdorp-Vogelaar, Iris
Rutter, Carolyn M
Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title_full Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title_fullStr Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title_full_unstemmed Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title_short Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
title_sort projected long-term effects of colorectal cancer screening disruptions following the covid-19 pandemic
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154022/
https://www.ncbi.nlm.nih.gov/pubmed/37129468
http://dx.doi.org/10.7554/eLife.85264
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