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Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic
The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing scree...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154022/ https://www.ncbi.nlm.nih.gov/pubmed/37129468 http://dx.doi.org/10.7554/eLife.85264 |
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author | Nascimento de Lima, Pedro van den Puttelaar, Rosita Hahn, Anne I Harlass, Matthias Collier, Nicholson Ozik, Jonathan Zauber, Ann G Lansdorp-Vogelaar, Iris Rutter, Carolyn M |
author_facet | Nascimento de Lima, Pedro van den Puttelaar, Rosita Hahn, Anne I Harlass, Matthias Collier, Nicholson Ozik, Jonathan Zauber, Ann G Lansdorp-Vogelaar, Iris Rutter, Carolyn M |
author_sort | Nascimento de Lima, Pedro |
collection | PubMed |
description | The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation. The impact of these disruptions on long-term CRC outcomes was measured by the number of life-years lost due to CRC screening disruptions compared to a scenario without any disruptions. While short-term delays in screening of 3–18 months are predicted to result in minor life-years loss, discontinuing screening could result in much more significant reductions in the expected benefits of screening. These results demonstrate that unequal recovery of screening following the pandemic can widen disparities in CRC outcomes and emphasize the importance of ensuring equitable recovery to screening following the pandemic. |
format | Online Article Text |
id | pubmed-10154022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-101540222023-05-03 Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic Nascimento de Lima, Pedro van den Puttelaar, Rosita Hahn, Anne I Harlass, Matthias Collier, Nicholson Ozik, Jonathan Zauber, Ann G Lansdorp-Vogelaar, Iris Rutter, Carolyn M eLife Epidemiology and Global Health The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation. The impact of these disruptions on long-term CRC outcomes was measured by the number of life-years lost due to CRC screening disruptions compared to a scenario without any disruptions. While short-term delays in screening of 3–18 months are predicted to result in minor life-years loss, discontinuing screening could result in much more significant reductions in the expected benefits of screening. These results demonstrate that unequal recovery of screening following the pandemic can widen disparities in CRC outcomes and emphasize the importance of ensuring equitable recovery to screening following the pandemic. eLife Sciences Publications, Ltd 2023-05-02 /pmc/articles/PMC10154022/ /pubmed/37129468 http://dx.doi.org/10.7554/eLife.85264 Text en © 2023, Nascimento de Lima et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Epidemiology and Global Health Nascimento de Lima, Pedro van den Puttelaar, Rosita Hahn, Anne I Harlass, Matthias Collier, Nicholson Ozik, Jonathan Zauber, Ann G Lansdorp-Vogelaar, Iris Rutter, Carolyn M Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title | Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title_full | Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title_fullStr | Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title_full_unstemmed | Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title_short | Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic |
title_sort | projected long-term effects of colorectal cancer screening disruptions following the covid-19 pandemic |
topic | Epidemiology and Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154022/ https://www.ncbi.nlm.nih.gov/pubmed/37129468 http://dx.doi.org/10.7554/eLife.85264 |
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