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Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

Nephronophthisis (NPHP) is a ciliopathy characterized by renal fibrosis and cyst formation, and accounts for a significant portion of end stage renal disease in children and young adults. Currently, no targeted therapy is available for this disease. INVS/NPHP2 is one of the over 25 NPHP genes identi...

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Detalles Bibliográficos
Autores principales: Li, Yuanyuan, Xu, Wenyan, Makova, Svetlana, Brueckner, Martina, Sun, Zhaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154023/
https://www.ncbi.nlm.nih.gov/pubmed/36920028
http://dx.doi.org/10.7554/eLife.82395