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Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity

PURPOSE: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP...

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Autores principales: Qiu, Mei-qing, Wang, Hui-jun, Ju, Ya-fei, Sun, Li, Liu, Zhen, Wang, Tao, Kan, Shi-feng, Yang, Zhen, Cui, Ya-yun, Ke, You-qiang, He, Hong-min, Zhang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Gastric Cancer Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154133/
https://www.ncbi.nlm.nih.gov/pubmed/37129157
http://dx.doi.org/10.5230/jgc.2023.23.e19
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author Qiu, Mei-qing
Wang, Hui-jun
Ju, Ya-fei
Sun, Li
Liu, Zhen
Wang, Tao
Kan, Shi-feng
Yang, Zhen
Cui, Ya-yun
Ke, You-qiang
He, Hong-min
Zhang, Shu
author_facet Qiu, Mei-qing
Wang, Hui-jun
Ju, Ya-fei
Sun, Li
Liu, Zhen
Wang, Tao
Kan, Shi-feng
Yang, Zhen
Cui, Ya-yun
Ke, You-qiang
He, Hong-min
Zhang, Shu
author_sort Qiu, Mei-qing
collection PubMed
description PURPOSE: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC. MATERIALS AND METHODS: We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq). RESULTS: Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics. CONCLUSIONS: These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.
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spelling pubmed-101541332023-05-04 Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity Qiu, Mei-qing Wang, Hui-jun Ju, Ya-fei Sun, Li Liu, Zhen Wang, Tao Kan, Shi-feng Yang, Zhen Cui, Ya-yun Ke, You-qiang He, Hong-min Zhang, Shu J Gastric Cancer Original Article PURPOSE: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC. MATERIALS AND METHODS: We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq). RESULTS: Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics. CONCLUSIONS: These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target. The Korean Gastric Cancer Association 2023-04 2023-04-25 /pmc/articles/PMC10154133/ /pubmed/37129157 http://dx.doi.org/10.5230/jgc.2023.23.e19 Text en Copyright © 2023. Korean Gastric Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Qiu, Mei-qing
Wang, Hui-jun
Ju, Ya-fei
Sun, Li
Liu, Zhen
Wang, Tao
Kan, Shi-feng
Yang, Zhen
Cui, Ya-yun
Ke, You-qiang
He, Hong-min
Zhang, Shu
Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title_full Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title_fullStr Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title_full_unstemmed Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title_short Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity
title_sort fatty acid binding protein 5 (fabp5) promotes aggressiveness of gastric cancer through modulation of tumor immunity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154133/
https://www.ncbi.nlm.nih.gov/pubmed/37129157
http://dx.doi.org/10.5230/jgc.2023.23.e19
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