Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the interaction between its receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2). Spike RBD has been reported to adopt two primary conformations, a closed conformation in which the binding site...

Descripción completa

Detalles Bibliográficos
Autores principales: Egri, Shawn B., Wang, Xue, Díaz-Salinas, Marco A., Luban, Jeremy, Dudkina, Natalya V., Munro, James B., Shen, Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154187/
https://www.ncbi.nlm.nih.gov/pubmed/37137903
http://dx.doi.org/10.1038/s41467-023-38251-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154187/
https://www.ncbi.nlm.nih.gov/pubmed/37137903
http://dx.doi.org/10.1038/s41467-023-38251-9

Ejemplares similares