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Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the interaction between its receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2). Spike RBD has been reported to adopt two primary conformations, a closed conformation in which the binding site...

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Detalles Bibliográficos
Autores principales:	Egri, Shawn B., Wang, Xue, Díaz-Salinas, Marco A., Luban, Jeremy, Dudkina, Natalya V., Munro, James B., Shen, Kuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154187/ https://www.ncbi.nlm.nih.gov/pubmed/37137903 http://dx.doi.org/10.1038/s41467-023-38251-9

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