Impaired CD4(+) T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination

Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of mRNA vaccines remains unclear. Using a vaccinated cohort (n = 216), we demonstrated that older adults (aged ≥65 years) had fewer vaccine-induced spike-specific CD4(+) T cells including CXCR3(+) circulating foll...

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Detalles Bibliográficos
Autores principales: Jo, Norihide, Hidaka, Yu, Kikuchi, Osamu, Fukahori, Masaru, Sawada, Takeshi, Aoki, Masahiko, Yamamoto, Masaki, Nagao, Miki, Morita, Satoshi, Nakajima, Takako E., Muto, Manabu, Hamazaki, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154196/
https://www.ncbi.nlm.nih.gov/pubmed/37118516
http://dx.doi.org/10.1038/s43587-022-00343-4

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