Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Aging is a critical risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efficacy. The immune responses to inactivated vaccine for older adults, and the underlying mechanisms of potential differences to young adults, are still unclear. Here we show that neutralizing a...

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Detalles Bibliográficos
Autores principales: Xiao, Chanchan, Ren, Zhiyao, Zhang, Bei, Mao, Lipeng, Zhu, Guodong, Gao, Lijuan, Su, Jun, Ye, Jiezhou, Long, Ze, Zhu, Yue, Chen, Pengfei, Su, Xiangmeng, Zhou, Tong, Huang, Yanhao, Chen, Xiongfei, Xie, Chaojun, Yuan, Jun, Hu, Yutian, Zheng, Jingshan, Wang, Zhigang, Lou, Jianrong, Yang, Xiang, Kuang, Zhiqiang, Zhang, Hongyi, Wang, Pengcheng, Liang, Xiaofeng, Luo, Oscar Junhong, Chen, Guobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154213/
https://www.ncbi.nlm.nih.gov/pubmed/37117789
http://dx.doi.org/10.1038/s43587-023-00379-0

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