Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here we report the characterization of neuronal APOE...

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Detalles Bibliográficos
Autores principales: Koutsodendris, Nicole, Blumenfeld, Jessica, Agrawal, Ayushi, Traglia, Michela, Grone, Brian, Zilberter, Misha, Yip, Oscar, Rao, Antara, Nelson, Maxine R., Hao, Yanxia, Thomas, Reuben, Yoon, Seo Yeon, Arriola, Patrick, Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154214/
https://www.ncbi.nlm.nih.gov/pubmed/37118426
http://dx.doi.org/10.1038/s43587-023-00368-3

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